Literature DB >> 1285325

Immunotoxins to human small-cell lung cancer.

E J Wawrzynczak1, E J Derbyshire.   

Abstract

Ricin A chain ITs directed against a variety of the common cell-surface antigens associated with SCLC exerted selective toxic effects on SCLC cell lines. The potency of the cytotoxic effects matched or exceeded that previously reported for ricin A chain ITs directed against identical or similar antigens on other types of carcinoma, suggesting that SCLC may be uniquely sensitive to this type of IT.

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Year:  1992        PMID： 1285325     DOI： 10.1007/BF02789474

Source DB:  PubMed          Journal:  Cell Biophys        ISSN： 0163-4992


  10 in total

1.  An anti-mucin immunotoxin BrE-3-ricin A-chain is potently and selectively toxic to human small-cell lung cancer.

Authors:  E J Derbyshire; E J Wawrzynczak
Journal:  Int J Cancer       Date:  1992-10-21       Impact factor: 7.396

2.  Cytotoxic properties of a ricin A chain immunotoxin recognising the cluster-5A antigen associated with human small-cell lung cancer.

Authors:  E J Derbyshire; R A Stahel; E J Wawrzynczak
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

3.  Monoclonal antibodies recognising the cluster 2 antigen associated with human small cell lung cancer mediate the toxic effects of ricin A chain in an indirect assay of immunotoxin cytotoxicity.

Authors:  E J Derbyshire; E J Wawrzynczak
Journal:  Br J Cancer Suppl       Date:  1991-06

4.  Potentiation of a weakly active ricin A chain immunotoxin recognizing the neural cell adhesion molecule.

Authors:  E J Derbyshire; R A Stahel; E J Wawrzynczak
Journal:  Clin Exp Immunol       Date:  1992-09       Impact factor: 4.330

5.  CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas.

Authors:  D Jackson; R Waibel; E Weber; J Bell; R A Stahel
Journal:  Cancer Res       Date:  1992-10-01       Impact factor: 12.701

6.  Action of a CD24-specific deglycosylated ricin-A-chain immunotoxin in conventional and novel models of small-cell-lung-cancer xenograft.

Authors:  U Zangemeister-Wittke; H P Lehmann; R Waibel; E J Wawrzynczak; R A Stahel
Journal:  Int J Cancer       Date:  1993-02-01       Impact factor: 7.396

7.  Potent cytotoxic action of the immunotoxin SWA11-ricin A chain against human small cell lung cancer cell lines.

Authors:  E J Derbyshire; R V Henry; R A Stahel; E J Wawrzynczak
Journal:  Br J Cancer       Date:  1992-09       Impact factor: 7.640

Review 8.  Systemic immunotoxin therapy of cancer: advances and prospects.

Authors:  E J Wawrzynczak
Journal:  Br J Cancer       Date:  1991-10       Impact factor: 7.640

9.  Refinement of an indirect immunotoxin assay of monoclonal antibodies recognising the human small cell lung cancer cluster 2 antigen.

Authors:  E J Derbyshire; L de Leij; E J Wawrzynczak
Journal:  Br J Cancer       Date:  1993-06       Impact factor: 7.640

10.  Molecular and biological properties of an abrin A chain immunotoxin designed for therapy of human small cell lung cancer.

Authors:  E J Wawrzynczak; U Zangemeister-Wittke; R Waibel; R V Henry; G D Parnell; A J Cumber; M Jones; R A Stahel
Journal:  Br J Cancer       Date:  1992-08       Impact factor: 7.640
  10 in total

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