| Literature DB >> 12852976 |
Phaik-Eng Sum1, David How, Nancy Torres, Howard Newman, Peter J Petersen, Tarek S Mansour.
Abstract
A series of benzoxazole derivatives of the mannopeptimycin glycopeptide antibiotics was synthesized via a novel benzoxazole formation reaction by treating aminophenol of mannopeptimycin-beta with an aldehyde and DDQ in DMF. Some of these derivatives (e.g., 5b, 5d, 5m, and 7b) showed good activity against Gram-(+) bacteria when compared to the parent compound mannopeptimycin-beta.Entities:
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Year: 2003 PMID： 12852976 DOI： 10.1016/s0960-894x(03)00512-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823