Literature DB >> 12852951

2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists.

Kevin J Hodgetts1, Taeyoung Yoon, Jianhua Huang, Michael Gulianello, Andrzej Kieltyka, Renee Primus, Robbin Brodbeck, Stéphane De Lombaert, Darío Doller.   

Abstract

The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents

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Year:  2003        PMID: 12852951     DOI: 10.1016/s0960-894x(03)00483-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Predictivity approach for quantitative structure-property models. Application for blood-brain barrier permeation of diverse drug-like compounds.

Authors:  Sorana D Bolboacă; Lorentz Jäntschi
Journal:  Int J Mol Sci       Date:  2011-07-05       Impact factor: 5.923

  1 in total

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