Literature DB >> 12852945

Copper complex of hydroxyl-substituted triazamacrocyclic ligand and its antitumor activity.

Feng Liang1, Chengtai Wu, Huakuan Lin, Tao Li, Dongzhao Gao, Zhaoyang Li, Jun Wei, Congyi Zheng, Mengxiang Sun.   

Abstract

The protonation constants and the stability constants for the formation of copper (II) complex of the ligand [1,4,7] Triazecan-9-ol (L) were presented. Antitumor activity of CuL complex was reported. Preliminary pharmacological tests showed that it had antitumor activity against HXO-RB44 and BEL-7402 cell lines in vitro. Nuclei of [CuL]-stimulated BEL-7402 cells clearly exhibited condensation and break down into chromatin clumps typical of apoptosis. Also it exhibited perturbation effects to BEL-7402 cell lines cycle and further studies showed that it could cleave supercoiled DNA (pBR 322) to nicked and linear DNA.

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Year:  2003        PMID： 12852945     DOI： 10.1016/s0960-894x(03)00489-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Evaluation of antiproliferative activities and apoptosis induction caused by copper(II)-benzothiazolesulfonamide complexes in Jurkat T lymphocytes and Caco-2 cells.

Authors:  Marta González-Alvarez; Gloria Alzuet; Joaquín Borrás; Lucas del Castillo-Agudo; Jose Manuel Montejo-Bernardo; Angel Gutiérrez-Rodríguez; Santiago García-Granda
Journal:  J Biol Inorg Chem       Date:  2008-07-24       Impact factor: 3.358

2.  Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats.

Authors:  Maryam Hajrezaie; Pouya Hassandarvish; Soheil Zorofchian Moghadamtousi; Nura Suleiman Gwaram; Shahram Golbabapour; Abdrabuh Najihussien; Amel Abdullah Almagrami; Maryam Zahedifard; Elham Rouhollahi; Hamed Karimian; Somaye Fani; Behnam Kamalidehghan; Nazia Abdul Majid; Hapipah Mohd Ali; Mahmood Ameen Abdulla
Journal:  PLoS One       Date:  2014-03-11       Impact factor: 3.240

3.  Evaluation of Transition Metal Complexes of Benzimidazole-Derived Scaffold as Promising Anticancer Chemotherapeutics.

Authors:  Afzal Hussain; Mohamed F AlAjmi; Md Tabish Rehman; Azmat Ali Khan; Perwez Alam Shaikh; Rais Ahmad Khan
Journal:  Molecules       Date:  2018-05-21       Impact factor: 4.411

4.  Cadmium(II) compounds of the bis-cyanoethyl derivative (LCX) of Me8[14]aneC (LC): characterization and antibacterial studies.

Authors:  Avijit Chakraborty; Saswata Rabi; Lucky Dey; Debashis Palit; Benu Kumar Dey; Edward R T Tiekink; Tapashi Ghosh Roy
Journal:  Heliyon       Date:  2022-06-07
  4 in total

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