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Literature DB >> 12852848

Chemical genetics: adding to the developmental biology toolbox.

Abstract

Recent advances in cell and molecular biology have generated important tools to probe developmental questions. In addition, new genetic model systems such as Danio rerio now make large-scale vertebrate early developmental mutant screens feasible. Nonetheless, some developmental questions remain difficult to study because of the need for finer temporal, spatial, or tuneable control of gene function within a developmental system. New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.

Entities: Species

Mesh：

Substances：
Teratogens

Year: 2003 PMID： 12852848 DOI： 10.1016/s1534-5807(03)00200-4

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

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Cited

18 in total

1. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.

Authors: Wendy S Beane; Junji Morokuma; Dany S Adams; Michael Levin
Journal: Chem Biol Date: 2011-01-28

10. A Tribolium castaneum whole-embryo culture protocol for studying the molecular mechanisms and morphogenetic movements involved in insect development.

Authors: Constanza C Macaya; Patricio E Saavedra; Rodrigo E Cepeda; Viviana A Nuñez; Andres F Sarrazin
Journal: Dev Genes Evol Date: 2016-01-06 Impact factor: 0.900

Chemical genetics: adding to the developmental biology toolbox.

1. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.

2. A small-molecule switch for Golgi sulfotransferases.

3. Inverse drug screens: a rapid and inexpensive method for implicating molecular targets.

4. A directed approach for engineering conditional protein stability using biologically silent small molecules.

5. Phenotypic high-throughput screening in atherosclerosis research: focus on macrophages.

Review 6. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs.

Review 7. The application of phenotypic high-throughput screening techniques to cardiovascular research.

8. Novel Vein Patterns in Arabidopsis Induced by Small Molecules.

9. Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis.

10. A Tribolium castaneum whole-embryo culture protocol for studying the molecular mechanisms and morphogenetic movements involved in insect development.