Literature DB >> 12852747

Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.

Yuka Nakanishi1, Fang-Rong Chang, Chih-Chuang Liaw, Yang-Chang Wu, Kenneth F Bastow, Kuo-Hsiung Lee.   

Abstract

Several bioactive acetogenins were selective against 1A9 (ovarian cancer) cell replication but did not show a corresponding hyperactivity against other cell lines. The most active compound (26, molvizarin) was a selective inhibitor of 1A9 cell replication with a potency (ED(50) = 5 pg/mL) of over 1 million times more than that for other cell lines.

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Year:  2003        PMID： 12852747     DOI： 10.1021/jm020548b

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  10 in total

1.  Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs.

Authors:  Kyoko Nakagawa-Goto; Tzu-Hsuan Chen; Chieh-Yu Peng; Kenneth F Bastow; Jiu-Hong Wu; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2007-06-15       Impact factor: 7.446

2.  Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar Dry Forest.

Authors:  Ende Pan; Shugeng Cao; Peggy J Brodie; Martin W Callmander; Richard Randrianaivo; Stephan Rakotonandrasana; Etienne Rakotobe; Vincent E Rasamison; Karen TenDyke; Yongchun Shen; Edward M Suh; David G I Kingston
Journal:  J Nat Prod       Date:  2011-04-19       Impact factor: 4.050

3.  Synthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates.

Authors:  Jing-Fang Shi; Ping Wu; Xiao-Li Cheng; Xiao-Yi Wei; Zi-Hua Jiang
Journal:  Drug Des Devel Ther       Date:  2020-11-17       Impact factor: 4.162

4.  Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety.

Authors:  Kaito Ohta; Tetsuya Fushimi; Mutsumi Okamura; Akinobu Akatsuka; Shingo Dan; Hiroki Iwasaki; Masayuki Yamashita; Naoto Kojima
Journal:  RSC Adv       Date:  2022-05-25       Impact factor: 4.036

5.  Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.

Authors:  Chia-Lin Lee; Fang-Rong Chang; Ming-Hon Yen; Donglei Yu; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Yang-Chang Wu; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2009-02-27       Impact factor: 4.050

6.  Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections?

Authors:  Christophe Wiart
Journal:  Evid Based Complement Alternat Med       Date:  2007-09       Impact factor: 2.629

7.  The chemopotential effect of Annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of Acetogenin Annomuricin E in HT-29 cells: a bioassay-guided approach.

Authors:  Soheil Zorofchian Moghadamtousi; Elham Rouhollahi; Hamed Karimian; Mehran Fadaeinasab; Mohammad Firoozinia; Mahmood Ameen Abdulla; Habsah Abdul Kadir
Journal:  PLoS One       Date:  2015-04-10       Impact factor: 3.240

8.  Annonaceous acetogenins nanosuspensions stabilized by PCL-PEG block polymer: significantly improved antitumor efficacy.

Authors:  Jingyi Hong; Yanhong Li; Yijing Li; Yao Xiao; Haixue Kuang; Xiangtao Wang
Journal:  Int J Nanomedicine       Date:  2016-07-18

Review 9.  Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents.

Authors:  Siti Mariam Abdul Wahab; Ibrahim Jantan; Md Areeful Haque; Laiba Arshad
Journal:  Front Pharmacol       Date:  2018-06-20       Impact factor: 5.810

Review 10.  An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.

Authors:  Alexandra G Durán; M Teresa Gutiérrez; Francisco J R Mejías; José M G Molinillo; Francisco A Macías
Journal:  Molecules       Date:  2021-05-14       Impact factor: 4.411
  10 in total

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