Viruses as potential targets for therapy in HIV-associated malignancies.

Epstein-Barr virus or Kaposi's sarcoma herpesvirus--and, at times, both viruses--are present in the tumor cells of many HIV-associated malignancies. Their presence provides potential therapeutic targets for adoptive immunotherapy with antigen-specific T cells, vaccines to induce specific T-cell responses, and pharmacologic therapies to kill tumor cells or alter their malignant phenotype.