| Literature DB >> 12852446 |
K V S R Krishna Reddy1, J Moses Babu, Y Ravindra Kumar, S Vishnu Vardhan Reddy, M Kishore Kumar, S Eswaraiah, K Rama Subba Reddy, M Sayanarayana Reddy, B Vijaya Bhaskar, P K Dubey, K Vyas.
Abstract
Three unknown impurities in loratadine bulk drug at levels below 0.1% (ranging from 0.05 to 0.1%) were detected by a simple isocratic reversed-phase high performance liquid chromatography (HPLC). These impurities were isolated from mother liquor sample of loratadine using reversed-phase preparative HPLC. Based on the spectral data (IR, NMR and MS) the structures of these impurities were characterized as 11-(N-carboethoxy-4-piperidylidene)-6,11-dihydro-5H-benzo(5,6) cyclopenta(1,2-b)-pyridine (I), 8-bromo-11-(N-carboethoxy-4-piperidylidene)-6,11-dihydro-5H-benzo(5,6) cyclopenta (1,2-b)-pyridine (II) and 8-chloro-11-(N-carboethoxy-4-piperidylidene)-5H-benzo(5,6) cyclopenta (1,2-b)-pyridine (III). The synthesis of these impurities was discussed.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12852446 DOI： 10.1016/s0731-7085(03)00056-6
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935