| Literature DB >> 12851685 |
Giovanna Maria Pierantoni1, Basilia Santulli, Irene Caliendo, Francesca Pentimalli, Gennaro Chiappetta, Nicola Zanesi, Massimo Santoro, Florencia Bulrich, Alfredo Fusco.
Abstract
We report the first case of acute lymphoblastic leukemia associated with a t(9;12)(p22;q14) translocation within the HMGA2 locus. The breakpoint lies in the 5' region. Fluorescence in situ hybridization with a BAC clone covering the 5' region produced three signals versus two signals with a BAC clone covering the 3' region including intron 3 of HMGA2, which harbors most of the breakpoints described in benign mesenchymal tumors. HMGA2 locus rearrangement was associated with overexpression of an HMGA2 mRNA that lacked a carboxy-terminal tail. These results suggest that the HMGA2 gene rearrangement may contribute to the malignancy in leukemias harboring a 12q translocation.Entities:
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Year: 2003 PMID： 12851685
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650