Literature DB >> 12851325

Melanocortin system and eating disorders.

Roger A H Adan1, Jacquelien J G Hillebrand, Corine De Rijke, Wouter Nijenhuis, Tom Vink, Keith M Garner, Martien J H Kas.   

Abstract

The melanocortin (MC) system is involved in the regulation of energy balance and in the development of obesity. Here we briefly review why we became interested in investigating whether the MC system - more particularly, the increased activity of the MC system - is also involved in disorders of negative energy balance. We provide evidence that suppression of increased MC receptor activity by treatment with the inverse agonist agouti-related peptide (AgRP) (83-132) rescues rats exposed to an animal model known as activity-based anorexia. Furthermore, we found a polymorphism, Ala67Thr AgRP, that was observed more frequently in anorexia nervosa.

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Year:  2003        PMID： 12851325     DOI： 10.1111/j.1749-6632.2003.tb03189.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  13 in total

1.  Agouti-related protein segments outside of the receptor binding core are required for enhanced short- and long-term feeding stimulation.

Authors:  Michael E Madonna; Jennifer Schurdak; Ying-Kui Yang; Stephen Benoit; Glenn L Millhauser
Journal:  ACS Chem Biol       Date:  2011-12-30       Impact factor: 5.100

2.  Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist.

Authors:  Katlyn A Fleming; Katie T Freeman; Mike D Powers; Radleigh G Santos; Ginamarie Debevec; Marc A Giulianotti; Richard A Houghten; Skye R Doering; Clemencia Pinilla; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2019-02-28       Impact factor: 7.446

3.  Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.

Authors:  Katlyn A Fleming; Mark D Ericson; Katie T Freeman; Danielle N Adank; Mary M Lunzer; Stacey L Wilber; Carrie Haskell-Luevano
Journal:  ACS Chem Neurosci       Date:  2018-02-13       Impact factor: 4.418

4.  Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.

Authors:  Mark D Ericson; Katie T Freeman; Sathya M Schnell; Katlyn A Fleming; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2017-10-04       Impact factor: 7.446

5.  Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.

Authors:  Mark D Ericson; Andrzej Wilczynski; Nicholas B Sorensen; Zhimin Xiang; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2015-04-21       Impact factor: 7.446

6.  Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists.

Authors:  Katlyn A Fleming; Katie T Freeman; Mark D Ericson; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2018-08-16       Impact factor: 7.446

7.  Obesity-related genetic variants, human pigmentation, and risk of melanoma.

Authors:  Xin Li; Liming Liang; Mingfeng Zhang; Fengju Song; Hongmei Nan; Li-E Wang; Qingyi Wei; Jeffrey E Lee; Christopher I Amos; Abrar A Qureshi; Jiali Han
Journal:  Hum Genet       Date:  2013-03-29       Impact factor: 4.132

8.  Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression.

Authors:  Lydiane Funkelstein; Thomas Toneff; Charles Mosier; Shin-Rong Hwang; Felix Beuschlein; Urs D Lichtenauer; Thomas Reinheckel; Christoph Peters; Vivian Hook
Journal:  J Biol Chem       Date:  2008-10-10       Impact factor: 5.157

9.  Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity.

Authors:  Min Chen; Minying Cai; David McPherson; Victor Hruby; Carroll M Harmon; Yingkui Yang
Journal:  Biochem Pharmacol       Date:  2008-09-30       Impact factor: 5.858

10.  Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite.

Authors:  Mardi S Byerly; Roy D Swanson; Nina N Semsarzadeh; Patrick S McCulloh; Kiwook Kwon; Susan Aja; Timothy H Moran; G William Wong; Seth Blackshaw
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-04-10       Impact factor: 3.619
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