Literature DB >> 12851294

Melanocortin receptors: ligands and proteochemometrics modeling.

J E S Wikberg1, F Mutulis, I Mutule, S Veiksina, M Lapinsh, R Petrovska, P Prusis.   

Abstract

The melanocortin receptors exist in five subtypes, MC(1-5)R. These receptors participate in important regulations of the immune system, central behavior, and endocrine and exocrine glands. Here we provide a short review on MCR subtype selective peptides and organic compounds with activity on the MCRs, developed in our laboratory. Also provided is an overview of our new proteochemometric modeling technology, which has been applied to model the interaction of MSH peptides with the MCRs.

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Year:  2003        PMID： 12851294     DOI： 10.1111/j.1749-6632.2003.tb03158.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  4 in total

1.  Computer aided selection of candidate vaccine antigens.

Authors:  Darren R Flower; Isabel K Macdonald; Kamna Ramakrishnan; Matthew N Davies; Irini A Doytchinova
Journal:  Immunome Res       Date:  2010-11-03

2.  Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling.

Authors:  Eva Freyhult; Peteris Prusis; Maris Lapinsh; Jarl E S Wikberg; Vincent Moulton; Mats G Gustafsson
Journal:  BMC Bioinformatics       Date:  2005-03-10       Impact factor: 3.169

3.  Benchmarking of protein descriptor sets in proteochemometric modeling (part 1): comparative study of 13 amino acid descriptor sets.

Authors:  Gerard Jp van Westen; Remco F Swier; Jörg K Wegner; Adriaan P Ijzerman; Herman Wt van Vlijmen; Andreas Bender
Journal:  J Cheminform       Date:  2013-09-23       Impact factor: 5.514

4.  Benchmarking of protein descriptor sets in proteochemometric modeling (part 2): modeling performance of 13 amino acid descriptor sets.

Authors:  Gerard Jp van Westen; Remco F Swier; Isidro Cortes-Ciriano; Jörg K Wegner; John P Overington; Adriaan P Ijzerman; Herman Wt van Vlijmen; Andreas Bender
Journal:  J Cheminform       Date:  2013-09-24       Impact factor: 5.514
  4 in total

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