Literature DB >> 12850423

Fatal hepatic failure following accidental tramadol overdose.

M B Loughrey1, C M Loughrey, S Johnston, D O'Rourke.   

Abstract

A case of fatal overdose of tramadol is described, occurring in a 67-year-old man with painful rib fractures who accidentally ingested more than the recommended daily dose. The mode of death was acute liver failure due to fulminant hepatic necrosis. Post-mortem toxicology was negative apart from revealing a blood tramadol concentration well above the normal therapeutic range. This is the first report of fatal tramadol ingestion occurring in a therapeutic setting and also the first tramadol-related death where the mechanism was liver failure.

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Year:  2003        PMID： 12850423     DOI： 10.1016/s0379-0738(03)00132-4

Source DB:  PubMed          Journal:  Forensic Sci Int        ISSN： 0379-0738            Impact factor:   2.395


  9 in total

1.  Factors related to seizure in tramadol poisoning and its blood concentration.

Authors:  Fakhreddin Taghaddosinejad; Omid Mehrpour; Reza Afshari; Alireza Seghatoleslami; Mohammad Abdollahi; Richard C Dart
Journal:  J Med Toxicol       Date:  2011-09

2.  The molecular and biochemical insight view of lycopene in ameliorating tramadol-induced liver toxicity in a rat model: implication of oxidative stress, apoptosis, and MAPK signaling pathways.

Authors:  Kadry M Sadek; Mohamed A Lebda; Tarek K Abouzed; Sherif M Nasr; Yasser El-Sayed
Journal:  Environ Sci Pollut Res Int       Date:  2018-09-24       Impact factor: 4.223

3.  Tramadol half life is dose dependent in overdose.

Authors:  Hamid Khosrojerdi; Ghazal Alipour Talesh; Gholam Hassan Danaei; Sara Shokooh Saremi; Afrouz Adab; Reza Afshari
Journal:  Daru       Date:  2015-02-26       Impact factor: 3.117

4.  Tramadol-induced hepato- and nephrotoxicity in rats: Role of Curcumin and Gallic acid as antioxidants.

Authors:  Salah A Sheweita; Ainour A Almasmari; Sabah G El-Banna
Journal:  PLoS One       Date:  2018-08-15       Impact factor: 3.240

5.  Rhabdomyolysis and acute kidney injury due to suicide attempt with tramadol: A rare case report.

Authors:  Farhad Gholami; Mahdieh Sadeghi; Zakaria Zakariaei; Mostafa Soleymani; Abdollah Malakian
Journal:  Clin Case Rep       Date:  2022-01-08

Review 6.  Opioid Drugs in Patients With Liver Disease: A Systematic Review.

Authors:  Hassan Soleimanpour; Saeid Safari; Kavous Shahsavari Nia; Sarvin Sanaie; Seyed Moayed Alavian
Journal:  Hepat Mon       Date:  2016-03-06       Impact factor: 0.660

7.  Effect of Nigella sativa Linn oil on tramadol-induced hepato- and nephrotoxicity in adult male albino rats.

Authors:  A Elkhateeb; I El Khishin; O Megahed; F Mazen
Journal:  Toxicol Rep       Date:  2015-03-14

8.  The effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin.

Authors:  Farideh Baghishani; Abbas Mohammadipour; Hossain Hosseinzadeh; Mahmoud Hosseini; Alireza Ebrahimzadeh-Bideskan
Journal:  Metab Brain Dis       Date:  2018-02-22       Impact factor: 3.584

9.  Melatonin and N- Acetylcysteine as Remedies for Tramadol-Induced Hepatotoxicity in Albino Rats.

Authors:  Elias Adikwu; Bonsome Bokolo
Journal:  Adv Pharm Bull       Date:  2017-09-25
  9 in total

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