Literature DB >> 12850334

Continuous flow reactors for drug discovery.

Paul Watts1, Stephen J Haswell.   

Abstract

To develop a new generation of drugs, pharmaceutical companies need to be able to synthesize and screen novel chemicals with enhanced speed. New technology that would enable a cost-neutral increase in the number of potential drug candidates would provide a distinct competitive advantage. The miniaturisation of chemical reactors offers many fundamental and practical advantages of relevance to the pharmaceutical industry, which is constantly searching for controllable, information-rich, high-throughput and environmentally friendly methods of producing compounds with a high degree of chemical selectivity. This article reviews the current and future applications of micro reactors that could enhance the drug discovery process.

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Year:  2003        PMID: 12850334     DOI: 10.1016/s1359-6446(03)02732-6

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  3 in total

1.  A droplet-based microfluidic platform enables high-throughput combinatorial optimization of cyanobacterial cultivation.

Authors:  Jialan Cao; David A Russo; Ting Xie; G Alexander Groß; Julie A Z Zedler
Journal:  Sci Rep       Date:  2022-09-15       Impact factor: 4.996

2.  Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS).

Authors:  Gjergji Shore; Michael Tsimerman; Michael G Organ
Journal:  Beilstein J Org Chem       Date:  2009-07-21       Impact factor: 2.883

Review 3.  Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Authors:  István M Mándity; Sándor B Ötvös; Ferenc Fülöp
Journal:  ChemistryOpen       Date:  2015-05-20       Impact factor: 2.911

  3 in total

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