Literature DB >> 12849761

L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease.

Roshan Cools1, Roger A Barker, Barbara J Sahakian, Trevor W Robbins.   

Abstract

In the current study we investigated the role of dopamine in attentional and socio-emotional functioning by examining effects of withdrawing dopaminergic medication in patients with Parkinson's disease (PD). Patients "on" medication exhibited abnormal betting strategies on a task of decision-making, reflecting impulsive behaviour and/or delay aversion, whilst the same patients "off" medication exhibited abnormally increased switch costs when switching between two tasks, reflecting attentional inflexibility. Hence, these data replicate and extend previous findings that dopaminergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of dopamine function in underlying cortico-striatal circuitry.

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Year:  2003        PMID： 12849761     DOI： 10.1016/s0028-3932(03)00117-9

Source DB:  PubMed          Journal:  Neuropsychologia        ISSN： 0028-3932            Impact factor:   3.139


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