Literature DB >> 12846794

The contributions of deficient androgen action in spermatogenic disorders.

Robert Ochsenkühn1, David M De Kretser.   

Abstract

The contributions of deficient androgen actions in spermatogenic disorders causing idiopathic male infertility are reviewed. The physiological role of androgens in spermatogenesis, the mechanism of actions of testosterone and the clinical implication of androgen deficiency are explained. The role of mutations in the androgen receptor (AR) in idiopathic infertility and, in particular, the contribution of expanded cytosine-adenine-guanine (CAG) repeats in exon 1 of the AR gene to the occurrence of male idiopathic infertility is highlighted. Possible future aspects of treatment for such patients are discussed.

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Year:  2003        PMID： 12846794     DOI： 10.1046/j.1365-2605.2003.00381.x

Source DB:  PubMed          Journal:  Int J Androl        ISSN： 0105-6263


  9 in total

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Authors:  Suresh Ramaswamy; Gerhard F Weinbauer
Journal:  Spermatogenesis       Date:  2015-01-26

2.  Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.

Authors:  Valeria Vasta; Masami Shimizu-Albergine; Joseph A Beavo
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-15       Impact factor: 11.205

3.  Preeclampsia and androgen receptor gene CAG repeat length: results from both children and women.

Authors:  Tanja Saarela; Jarmo Jääskeläinen; Sirpa Tenhola; Raimo Voutilainen; Seppo Heinonen
Journal:  J Assist Reprod Genet       Date:  2005-08       Impact factor: 3.412

Review 4.  Androgens and spermatogenesis: lessons from transgenic mouse models.

Authors:  Guido Verhoeven; Ariane Willems; Evi Denolet; Johannes V Swinnen; Karel De Gendt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-05-27       Impact factor: 6.237

Review 5.  Androgens and male fertility.

Authors:  G R Dohle; M Smit; R F A Weber
Journal:  World J Urol       Date:  2003-10-18       Impact factor: 4.226

6.  Characterization and management of testicular pathology in McCune-Albright syndrome.

Authors:  Alison M Boyce; William H Chong; Thomas H Shawker; Peter A Pinto; W Marsten Linehan; Nisan Bhattacharryya; Maria J Merino; Frederick R Singer; Michael T Collins
Journal:  J Clin Endocrinol Metab       Date:  2012-06-28       Impact factor: 5.958

7.  Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human.

Authors:  Nina Hallmark; Marion Walker; Chris McKinnell; I Kim Mahood; Hayley Scott; Rosemary Bayne; Shiona Coutts; Richard A Anderson; Irene Greig; Keith Morris; Richard M Sharpe
Journal:  Environ Health Perspect       Date:  2006-12-19       Impact factor: 9.031

Review 8.  Effects of Bisphenols on Testicular Steroidogenesis.

Authors:  Federica Barbagallo; Rosita A Condorelli; Laura M Mongioì; Rossella Cannarella; Antonio Aversa; Aldo E Calogero; Sandro La Vignera
Journal:  Front Endocrinol (Lausanne)       Date:  2020-06-30       Impact factor: 5.555

9.  A Gly684Ala substitution in the androgen receptor is the cause for azoospermia in a Chinese family with mild androgen insensitivity syndrome and normal hormone levels.

Authors:  Yuan Yuan; Wen-Qing Xu; Ying Chen; Tao Luo; Hou-Yang Chen
Journal:  Front Genet       Date:  2022-09-09       Impact factor: 4.772
  9 in total

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