OBJECTIVE: Data have suggested that higher levels of nutrients are protective against HPV persistence and cervical neoplasia. This study assessed the role of circulating nutrients on clearance of oncogenic HPV infections. METHODS: Women were followed prospectively with visits at baseline and approximately 4- and 10-months post-baseline. At each visit, 15 oncogenic HPV types were determined. Plasma levels were assessed at the 4-month visit for retinol, carotenoids (i.e., alpha-, trans-beta-, cis-beta-carotene, alpha-, beta-cryptoxanthin, lutein, zeaxanthin, trans- and cis-lycopene), tocopherols (i.e., alpha-, delta-, and gamma-tocopherol), folate and vitamin B12. Using multivariate Cox proportional hazards models, time to clearance analyses of oncogenic HPV infections were conducted for 84 women with at least one oncogenic infection at baseline. Hazard ratios (HR) were estimated for the association of HPV clearance to each nutrient tertile and to determine linear trends. RESULTS: The likelihood of clearing an oncogenic HPV infection was significantly higher with increasing levels of trans-lycopene (p for trend, 0.025) and cis-lycopene (p for trend, 0.010). The adjusted hazard ratios of the highest tertiles of trans- and cis-lycopene were 2.79 (95% CI = 1.17-6.66) and 2.92 (95% CI = 1.28-6.63) compared with the lowest tertiles. CONCLUSIONS: Higher concentrations of trans- and cis-lycopene may reduce the time to clearance of an oncogenic HPV infection.
OBJECTIVE: Data have suggested that higher levels of nutrients are protective against HPV persistence and cervical neoplasia. This study assessed the role of circulating nutrients on clearance of oncogenic HPV infections. METHODS:Women were followed prospectively with visits at baseline and approximately 4- and 10-months post-baseline. At each visit, 15 oncogenic HPV types were determined. Plasma levels were assessed at the 4-month visit for retinol, carotenoids (i.e., alpha-, trans-beta-, cis-beta-carotene, alpha-, beta-cryptoxanthin, lutein, zeaxanthin, trans- and cis-lycopene), tocopherols (i.e., alpha-, delta-, and gamma-tocopherol), folate and vitamin B12. Using multivariate Cox proportional hazards models, time to clearance analyses of oncogenic HPV infections were conducted for 84 women with at least one oncogenic infection at baseline. Hazard ratios (HR) were estimated for the association of HPV clearance to each nutrient tertile and to determine linear trends. RESULTS: The likelihood of clearing an oncogenic HPV infection was significantly higher with increasing levels of trans-lycopene (p for trend, 0.025) and cis-lycopene (p for trend, 0.010). The adjusted hazard ratios of the highest tertiles of trans- and cis-lycopene were 2.79 (95% CI = 1.17-6.66) and 2.92 (95% CI = 1.28-6.63) compared with the lowest tertiles. CONCLUSIONS: Higher concentrations of trans- and cis-lycopene may reduce the time to clearance of an oncogenic HPV infection.
Authors: Erin M Siegel; Nitin Patel; Beibei Lu; Ji-Hyun Lee; Alan G Nyitray; Neal E Craft; Krystyna Frenkel; Luisa L Villa; Eduardo L Franco; Anna R Giuliano Journal: Int J Cancer Date: 2011-11-28 Impact factor: 7.396
Authors: Yurii B Shvetsov; Brenda Y Hernandez; Lynne R Wilkens; Pamela J Thompson; Adrian A Franke; Xuemei Zhu; Marc T Goodman Journal: Cancer Res Date: 2010-10-08 Impact factor: 12.701
Authors: Erin M Siegel; Neal E Craft; Eliane Duarte-Franco; Luisa L Villa; Eduardo L Franco; Anna R Giuliano Journal: Int J Cancer Date: 2007-02-01 Impact factor: 7.396
Authors: Sara C Soto-De León; Luisa Del Río-Ospina; Milena Camargo; Ricardo Sánchez; Darwin A Moreno-Pérez; Antonio Pérez-Prados; Manuel E Patarroyo; Manuel A Patarroyo Journal: BMC Infect Dis Date: 2014-07-16 Impact factor: 3.090