Literature DB >> 12845715

Augmentation of recombinant CH50 polypeptide on the function of macrophages of mice during chemotherapy.

G Zhang1, Z Feng, D Li, H Cao, H Zhang.   

Abstract

The immunosuppressive model of mice was made by intraperitoneal injection of cyclophosphamide. The effect of CH50, a recombinant polypeptide of human fibronectin, on macrophages of mice was observed. The results showed that continuous intraperitoneal injection of CH50 could prevent the reduction of the number of monocytes in periphery blood and abdominal cavity by chemotherapeutic agents, enhance the metabolic activity and cytotoxicity of macrophages and augment the proliferation of splenocytes. The results suggested that CH50 is a product which could be used to improve the efficacy of chemotherapy of tumors.

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Year:  2000        PMID： 12845715     DOI： 10.1007/bf02887040

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  7 in total

1.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

2.  Fibronectin fragments containing the RGDS cell-binding domain mediate monocyte migration into the rabbit lung. A potential mechanism for C5 fragment-induced monocyte lung accumulation.

Authors:  D E Doherty; P M Henson; R A Clark
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

3.  Interaction of the cell-binding domain of fibronectin with VLA-5 integrin induces monokine production in cultured human monocytes.

Authors:  T Takizawa; S Nishinarita; N Kitamura; J Hayakawa; H Kang; Y Tomita; K Mitamura; K Yamagami; T Horie
Journal:  Clin Exp Immunol       Date:  1995-08       Impact factor: 4.330

4.  Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

Authors:  A H Ding; C F Nathan; D J Stuehr
Journal:  J Immunol       Date:  1988-10-01       Impact factor: 5.422

5.  A new 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for testing macrophage cytotoxicity to L1210 and its drug-resistant cell lines in vitro.

Authors:  H Jiao; W Shen; Y Ohe; K Miura; T Tamura; N Saijo
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

6.  Up-regulation of VLA-5 expression during monocytic differentiation and its role in negative control of the survival of peripheral blood monocytes.

Authors:  Y Terui; Y Furukawa; T Sakai; J Kikuchi; H Sugahara; Y Kanakura; S Kitagawa; Y Miura
Journal:  J Immunol       Date:  1996-03-01       Impact factor: 5.422

7.  Antimetastatic effect by anti-adhesion therapy with cell-adhesive peptide of fibronectin in combination with anticancer drugs.

Authors:  I Saiki; J Yoneda; H Kobayashi; Y Igarashi; H Komazawa; Y Ishizaki; I Kato; I Azuma
Journal:  Jpn J Cancer Res       Date:  1993-03
  7 in total
  1 in total

1.  Effects of gene tranfection with CH50 polypeptide on the invasion ability of bladder cancer cell line BIU-87.

Authors:  Zhuang Wu; Zhong Chen; Zhangqun Ye; Jianhua Zhang; Shiqiao Ye; Guimei Zhang; Zuohua Feng
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2005
  1 in total

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