Seppo Kähkönen1,2, Jyrki Ahveninen3,4, Iiro P Jääskeläinen5,3,4,6, Sirpa Pennanen7, Jyrki Liesivuori8, Vadim V Nikulin5,9. 1. Cognitive Brain Research Unit, University of Helsinki, Helsinki, Finland. seppo.kahkonen@helsinki.fi. 2. BioMag Laboratory, Helsinki University Central Hospital, PO Box 340, 00290, Helsinki, Finland. seppo.kahkonen@helsinki.fi. 3. Massachusetts General Hospital-NMR Center, Harvard Medical School, Charlestown, Mass., USA. 4. Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, Helsinki, Finland. 5. BioMag Laboratory, Helsinki University Central Hospital, PO Box 340, 00290, Helsinki, Finland. 6. Apperception & Cortical Dynamics, Department of Psychology, University of Helsinki, Finland. 7. Occupational Hygiene and Toxicology Section, Kuopio Regional Institute of Occupational Health, Kuopio, Finland. 8. Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland. 9. Department of Clinical Neurophysiology, Karolinska Hospital, Stockholm, Sweden.
Abstract
RATIONALE: Serotonin is shown to regulate the activity of primary auditory cortex, but little is known about serotonin modulation of other sensory cortices. METHODS: We investigated somatosensory evoked magnetic fields (SEF) to left median nerve stimulation in eight healthy subjects in a double-blind, controlled, cross-over design study after acute tryptophan depletion (ATD) and control mixture. SEFs were recorded with the whole-head magnetoencephalography 6 h after ingestion of mixtures. The SEF sources and strength were estimated by a least-squares fit of a single equivalent current dipole. RESULTS: ATD decreased the total and free TPR levels by 75 and 48% and control mixture increased them by 98% and 44%. ATD had no effect on the amplitudes or latencies of SEF components. The source locations of the responses were not significantly affected by ATD. CONCLUSION:Serotonin does not affect stimuli processing in the primary somatosensory cortex.
RCT Entities:
RATIONALE: Serotonin is shown to regulate the activity of primary auditory cortex, but little is known about serotonin modulation of other sensory cortices. METHODS: We investigated somatosensory evoked magnetic fields (SEF) to left median nerve stimulation in eight healthy subjects in a double-blind, controlled, cross-over design study after acute tryptophan depletion (ATD) and control mixture. SEFs were recorded with the whole-head magnetoencephalography 6 h after ingestion of mixtures. The SEF sources and strength were estimated by a least-squares fit of a single equivalent current dipole. RESULTS:ATD decreased the total and free TPR levels by 75 and 48% and control mixture increased them by 98% and 44%. ATD had no effect on the amplitudes or latencies of SEF components. The source locations of the responses were not significantly affected by ATD. CONCLUSION:Serotonin does not affect stimuli processing in the primary somatosensory cortex.
Authors: T Dierks; S Barta; L Demisch; K Schmeck; E Englert; A Kewitz; K Maurer; F Poustka Journal: Psychopharmacology (Berl) Date: 1999-09-01 Impact factor: 4.530
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Authors: Seppo Kähkönen; Iiro P Jääskeläinen; Sirpa Pennanen; Jyrki Liesivuori; Jyrki Ahveninen Journal: Psychopharmacology (Berl) Date: 2002-09-04 Impact factor: 4.530
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