Literature DB >> 12843674

Three new cytotoxic acylspermidines from the soft coral, Sinularia sp.

Makoto Ojika1, Mohammad Kamrul Islam, Tomoaki Shintani, Yang Zhang, Tetsuji Okamoto, Youji Sakagami.   

Abstract

Three new acylated spermidines and two known related compounds were isolated from the Okinawan soft coral, Sinularia sp. These compounds were N',N",N"-trimethylspermidines that are acylated by a methyl-branched unsaturated fatty acid. These acylspermidines showed potent cytotoxicity against human tumor cell lines at an IC(50) value of 17 ng/ml and the induction of apoptotic phenomena.

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Year:  2003        PMID： 12843674     DOI： 10.1271/bbb.67.1410

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  10 in total

1.  Proteomic analysis of anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells.

Authors:  Chih-I Liu; Cheng-Chi Chen; Jiing-Chuan Chen; Jui-Hsin Su; Han Hsiang Huang; Jeff Yi-Fu Chen; Yu-Jen Wu
Journal:  Mar Drugs       Date:  2011-07-14       Impact factor: 6.085

2.  A great barrier reef Sinularia sp. yields two new cytotoxic diterpenes.

Authors:  Anthony D Wright; Jonathan L Nielson; Dianne M Tapiolas; Catherine H Liptrot; Cherie A Motti
Journal:  Mar Drugs       Date:  2012-07-31       Impact factor: 6.085

3.  An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

Authors:  Ching-Chyuan Su; Jui-Hsin Su; Jen-Jie Lin; Cheng-Chi Chen; Wen-Ing Hwang; Han Hsiang Huang; Yu-Jen Wu
Journal:  Mar Drugs       Date:  2011-12-13       Impact factor: 6.085

4.  Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.

Authors:  Yu-Jen Wu; Choo-Aun Neoh; Chia-Yu Tsao; Jui-Hsin Su; Hsing-Hui Li
Journal:  Int J Mol Sci       Date:  2015-07-20       Impact factor: 5.923

5.  13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression.

Authors:  Ching-Chyuan Su; Jeff Yi-Fu Chen; Zhong-Hao Din; Jui-Hsin Su; Zih-Yan Yang; Yi-Jen Chen; Robert Y L Wang; Yu-Jen Wu
Journal:  Mar Drugs       Date:  2014-10-23       Impact factor: 5.118

6.  Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.

Authors:  Jen-Jie Lin; Robert Y L Wang; Jiing-Chuan Chen; Chien-Chih Chiu; Ming-Hui Liao; Yu-Jen Wu
Journal:  Int J Mol Sci       Date:  2016-10-27       Impact factor: 5.923

7.  Furanocembranoid from the Okinawan soft coral Sinularia sp.

Authors:  Misaki Nagasaka; Kazuki Tani; Keisuke Nishikawa; Riri Kinjo; Takahiro Ishii
Journal:  Nat Prod Bioprospect       Date:  2022-03-02

8.  Polyoxygenated sterols from the South China Sea soft coral Sinularia sp.

Authors:  Rui Li; Chang-Lun Shao; Xin Qi; Xiu-Bao Li; Jing Li; Ling-Ling Sun; Chang-Yun Wang
Journal:  Mar Drugs       Date:  2012-06-26       Impact factor: 6.085

9.  Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells.

Authors:  Choo-Aun Neoh; Robert Y-L Wang; Zhong-Hao Din; Jui-Hsin Su; Yu-Kuei Chen; Feng-Jen Tsai; Shun-Hsiang Weng; Yu-Jen Wu
Journal:  Mar Drugs       Date:  2012-12-18       Impact factor: 5.118

10.  Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (soft corals) are capable of inhibiting the growth of human oral squamous cell carcinoma cells.

Authors:  Chia-Hua Liang; Guey-Horng Wang; Chih-Chuang Liaw; Mei-Feng Lee; Shih-Hao Wang; Da-Long Cheng; Tzung-Han Chou
Journal:  Mar Drugs       Date:  2008-11-03       Impact factor: 5.118
  10 in total

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