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Literature DB >> 12843596

Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.

Sunit Suksamrarn¹, Narisara Suwannapoch, Wong Phakhodee, Janthana Thanuhiranlert, Piniti Ratananukul, Nitirat Chimnoi, Apichart Suksamrarn.

Abstract

Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.

Entities: Chemical Species

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Year: 2003 PMID： 12843596 DOI： 10.1248/cpb.51.857

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

22 in total

1. A Method of Effectively Improved α-Mangostin Bioavailability.

Authors: Yan Zhao; Guosheng Tang; Qiang Tang; Jing Zhang; Yingying Hou; Enbo Cai; Shuangli Liu; Daihong Lei; Lianxue Zhang; Shijie Wang
Journal: Eur J Drug Metab Pharmacokinet Date: 2015-05-20 Impact factor: 2.441

2. In vivo toxicity and antitumor activity of mangosteen extract.

Authors: Nuttavut Kosem; Kazuhiro Ichikawa; Hideo Utsumi; Primchanien Moongkarndi
Journal: J Nat Med Date: 2012-05-24 Impact factor: 2.343

3. Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.

Authors: Young-Won Chin; A Douglas Kinghorn
Journal: Mini Rev Org Chem Date: 2008-11-01 Impact factor: 2.495

4. Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults.

Authors: Chureeporn Chitchumroonchokchai; Kenneth M Riedl; Sunit Suksumrarn; Steven K Clinton; A Douglas Kinghorn; Mark L Failla
Journal: J Nutr Date: 2012-03-07 Impact factor: 4.798

5. Effects of α-mangostin on apoptosis induction of human colon cancer.

Authors: Ramida Watanapokasin; Faongchat Jarinthanan; Yukio Nakamura; Nitisak Sawasjirakij; Amornmart Jaratrungtawee; Sunit Suksamrarn
Journal: World J Gastroenterol Date: 2011-04-28 Impact factor: 5.742

6. Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria.

Authors: Jean-Bosco Jouda; Jean-de-Dieu Tamokou; Céline Djama Mbazoa; Prodipta Sarkar; Prasanta Kumar Bag; Jean Wandji
Journal: Afr Health Sci Date: 2016-09 Impact factor: 0.927

Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.

1. A Method of Effectively Improved α-Mangostin Bioavailability.

2. In vivo toxicity and antitumor activity of mangosteen extract.

3. Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.

4. Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults.

5. Effects of α-mangostin on apoptosis induction of human colon cancer.

6. Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria.

7. Total Synthesis of Tovophyllin B.

8. α-Mangostin: anti-inflammatory activity and metabolism by human cells.

9. In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract.

10. Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G.