Literature DB >> 12843583

Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis.

Quan-Bin Han1, Ma-Lin Li, Sheng-Hong Li, Yi-Kun Mou, Zhong-Wen Lin, Han-Dong Sun.   

Abstract

Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.

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Year:  2003        PMID： 12843583     DOI： 10.1248/cpb.51.790

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  13 in total

1.  Oridonin Inhibits Cell Proliferation and Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

Authors:  Cai-hong Shang; Qing-qing Zhang; Jian-hua Zhou
Journal:  Inflammation       Date:  2016-04       Impact factor: 4.092

Review 2.  Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin.

Authors:  Wei Tian; Si-Yu Chen
Journal:  Chin J Integr Med       Date:  2013-04-02       Impact factor: 1.978

3.  Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1.

Authors:  Rong Zeng; Yan Chen; Shuai Zhao; Guo-hui Cui
Journal:  Acta Pharmacol Sin       Date:  2011-12-12       Impact factor: 6.150

4.  Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells.

Authors:  Ya-hong Zhang; Ying-liang Wu; Shin-ichi Tashiro; Satoshi Onodera; Takashi Ikejima
Journal:  Acta Pharmacol Sin       Date:  2011-09-05       Impact factor: 6.150

5.  Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line.

Authors:  Xiaoli Qi; Dianrui Zhang; Xia Xu; Feifei Feng; Guijie Ren; Qianqian Chu; Qiang Zhang; Keli Tian
Journal:  Int J Nanomedicine       Date:  2012-04-03

6.  Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma.

Authors:  Yuan-Fei Liu; Yun-Min Lu; Guo-Qiang Qu; Yuan Liu; Wei-Xiong Chen; Xiao-Hong Liao; Wu-Ming Kong
Journal:  Int J Mol Sci       Date:  2015-01-12       Impact factor: 5.923

Review 7.  Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance.

Authors:  Xi Liu; Jimin Xu; Jia Zhou; Qiang Shen
Journal:  Genes Dis       Date:  2020-07-05

8.  Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach.

Authors:  Eric S J Harris; Shugeng Cao; Sean D Schoville; Chengming Dong; Wenquan Wang; Zaiyou Jian; Zhongzhen Zhao; David M Eisenberg; Jon Clardy
Journal:  PLoS One       Date:  2012-11-27       Impact factor: 3.240

9.  Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis.

Authors:  Jia-Jun Liu; Yong Zhang; Wei-Bin Guang; Hong-Zhi Yang; Dong-Jun Lin; Ruo-Zhi Xiao
Journal:  Int J Mol Sci       Date:  2008-11-19       Impact factor: 6.208

10.  Phytotherapeutics Oridonin and Ponicidin show Additive Effects Combined with Irradiation in Pancreatic Cancer in Vitro.

Authors:  Jakob Liermann; Patrick Naumann; Franco Fortunato; Thomas E Schmid; Klaus-Josef Weber; Jürgen Debus; Stephanie E Combs
Journal:  Radiol Oncol       Date:  2017-11-29       Impact factor: 2.991
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