| Literature DB >> 12842079 |
Abstract
Understanding the mechanisms through which the abundance and activity of the Myc oncoprotein is regulated has been a major preoccupation of the cancer and transcription communities. New work, published in the May issue of Molecular Cell, reveals that ubiquitination of Myc by the oncogenic SCF(Skp2) complex not only promotes Myc turnover but is also required for Myc transcriptional activation, suggesting that Myc activity is "licensed" by ubiquitination.Entities:
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Year: 2003 PMID： 12842079 DOI： 10.1016/s1535-6108(03)00145-4
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743