Literature DB >> 12841641

The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.

Kumaravel Palanichamy Malarkodi1, Andithangal Venkatesan Balachandar, Palaninathan Varlakshmi.   

Abstract

Adriamycin widely used in the treatment of neoplastic conditions is nephrotoxic. In the present study the protective effect of lipoic acid was investigated in adriamycin-induced nephrotoxicity in adult male albino Wistar rats. Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans. Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity.

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Year:  2003        PMID： 12841641     DOI： 10.1023/a:1024175325850

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  49 in total

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  5 in total

1.  The effects of combined treatment with niacin and chromium on the renal tissues of hyperlipidemic rats.

Authors:  Meliha Sengezer Inceli; Sehnaz Bolkent; M Mutluhan Doger; Refiye Yanardag
Journal:  Mol Cell Biochem       Date:  2006-11-24       Impact factor: 3.396

2.  Protective effects of alpha-lipoic Acid on oleic Acid-induced acute lung injury in rats.

Authors:  Funda Gülcü Bulmuş; Mehmet Ferit Gürsu; Mehmet Hamdi Muz; Ihsan Yaman; Ozgür Bulmuş; Fatih Sakin
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Journal:  Eur J Clin Pharmacol       Date:  2012-11-22       Impact factor: 2.953

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Authors:  Ganapathy Amudha; Anthony Josephine; Palaninathan Varalakshmi
Journal:  Mol Cell Biochem       Date:  2007-01-16       Impact factor: 3.842

5.  Cardiovascular status of breast cancer patients before and after receiving anthracycline chemotherapy regimen.

Authors:  Zhaoying Dong; Zhaojun Liu; Siyu Chen; Changhong Zhang; Jun Xiao; Xiaoli Zhou
Journal:  Nurs Open       Date:  2021-09-30
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