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Literature DB >> 12841393

Localized relapse in bone marrow in a posttransplantation patient with t(6;9) acute myeloid leukemia.

Tetsuo Maeda¹, Satoru Kosugi, Hidetoshi Ujiie, Kazuoki Osumi, Takashi Fukui, Hitoshi Yoshida, Hirokazu Kashiwagi, Jun Ishikawa, Yoshiaki Tomiyama, Yuji Matsuzawa.

Abstract

We report a 38-year-old woman with t(6;9) acute myeloid leukemia who relapsed with localized leukemic cell growth in the bone marrow after she had undergone allogeneic bone marrow transplantation. The localized cell growth was first recognized by an apparent discrepancy in the DEK-CAN fusion transcript levels between the aspirates from the left and right iliac bone marrow. Magnetic resonance imaging of the iliac bone revealed localized cell accumulation in the left side. The nonhomogeneous and localized leukemic cell growth in this case may have been due to the graft-versus-leukemia effect following allogeneic transplantation with donor lymphocyte infusion. Serial monitoring of molecular markers for leukemia at different sites or magnetic resonance imaging of the bone marrow may be of value in detecting this type of relapse.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12841393 DOI： 10.1007/bf02986623

Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490

12 in total

Review 1. Detection of minimal residual disease in acute myeloid leukaemia: methodologies, clinical and biological significance.

Authors: J A Yin; K Tobal
Journal: Br J Haematol Date: 1999-09 Impact factor: 6.998

2. Loss of the DEK-CAN fusion transcript in a child with t(6;9) acute myeloid leukemia following chemotherapy and allogeneic bone marrow transplantation.

Authors: J Boer; H Mahmoud; S Raimondi; G Grosveld; R Krance
Journal: Leukemia Date: 1997-02 Impact factor: 11.528

Review 3. Donor lymphocyte infusion: the use of alloreactive and tumor-reactive lymphocytes for immunotherapy of malignant and nonmalignant diseases in conjunction with allogeneic stem cell transplantation.

Authors: Shimon Slavin; Shoshana Morecki; Lola Weiss; Reuven Or
Journal: J Hematother Stem Cell Res Date: 2002-04

4. Detection of minimal residual disease in patients with AML1/ETO-associated acute myeloid leukemia using a novel quantitative reverse transcription polymerase chain reaction assay.

Authors: G Marcucci; K J Livak; W Bi; M P Strout; C D Bloomfield; M A Caligiuri
Journal: Leukemia Date: 1998-09 Impact factor: 11.528

5. Combination chemotherapy with risk factor-adjusted dose attenuation for high-risk myelodysplastic syndrome and resulting leukemia in the multicenter study of the Japan Adult Leukemia Study Group (JALSG): results of an interim analysis.

Authors: T Okamoto; A Kanamaru; C Shimazaki; T Motoji; Y Takemoto; M Takahashi; T Fukushima; A Takeshita; G S Kusumoto; Y Kishimoto; S Yorimitsu; K Tsukuda; N Uike; N Arima; R Ohno
Journal: Int J Hematol Date: 2000-08 Impact factor: 2.490

6. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

Authors: M von Lindern; M Fornerod; S van Baal; M Jaegle; T de Wit; A Buijs; G Grosveld
Journal: Mol Cell Biol Date: 1992-04 Impact factor: 4.272

7. Nonhomogeneous distribution of leukemia in the bone marrow during minimal residual disease.

Authors: A C Martens; F W Schultz; A Hagenbeek
Journal: Blood Date: 1987-10 Impact factor: 22.113

Review 8. Translocation t(6;9)(p23;q34) in acute myeloid leukemia without myelodysplasia or basophilia: two cases and a review of the literature.

Authors: D M Lillington; P K MacCallum; T A Lister; B Gibbons
Journal: Leukemia Date: 1993-04 Impact factor: 11.528

9. Detection of minimal residual disease in a patient with acute myeloid leukemia and t(6;9) at the time of peripheral blood stem cell transplantation.

Authors: H Nakano; Y Shimamoto; K Suga; M Kobayashi
Journal: Acta Haematol Date: 1995 Impact factor: 2.195