STUDY OBJECTIVES: To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. DESIGN: Subjects were genotyped using polymerase chain reaction. PATIENTS OR PARTICIPANTS: Subjects with defined diurnal preference as determined by the Horne-Ostberg questionnaire and patients with delayed sleep phase syndrome. MEASUREMENTS AND RESULTS: The Per3 polymorphism correlated significantly with extreme diurnal preference, the longer allele associating with morningness and the shorter allele with eveningness. The shorter allele was strongly associated with the delayed sleep phase syndrome patients, 75% of whom were homozygous. CONCLUSION: The length of the Per3 repeat region identifies a potential genetic marker for extreme diurnal preference.
STUDY OBJECTIVES: To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. DESIGN: Subjects were genotyped using polymerase chain reaction. PATIENTS OR PARTICIPANTS: Subjects with defined diurnal preference as determined by the Horne-Ostberg questionnaire and patients with delayed sleep phase syndrome. MEASUREMENTS AND RESULTS: The Per3 polymorphism correlated significantly with extreme diurnal preference, the longer allele associating with morningness and the shorter allele with eveningness. The shorter allele was strongly associated with the delayed sleep phase syndromepatients, 75% of whom were homozygous. CONCLUSION: The length of the Per3 repeat region identifies a potential genetic marker for extreme diurnal preference.
Authors: Mikhil N Bamne; Hader Mansour; Timothy H Monk; Daniel J Buysse; Vishwajit L Nimgaonkar Journal: Sleep Med Rev Date: 2010-03-17 Impact factor: 11.609
Authors: Andrew S P Lim; Anne-Marie Chang; Joshua M Shulman; Towfique Raj; Lori B Chibnik; Sean W Cain; Katherine Rothamel; Christophe Benoist; Amanda J Myers; Charles A Czeisler; Aron S Buchman; David A Bennett; Jeanne F Duffy; Clifford B Saper; Philip L De Jager Journal: Ann Neurol Date: 2012-09 Impact factor: 10.422
Authors: Christopher M Ciarleglio; Kelli K Ryckman; Stein V Servick; Akiko Hida; Sam Robbins; Nancy Wells; Jennifer Hicks; Sydney A Larson; Joshua P Wiedermann; Krista Carver; Nalo Hamilton; Kenneth K Kidd; Judith R Kidd; Jeffrey R Smith; Jonathan Friedlaender; Douglas G McMahon; Scott M Williams; Marshall L Summar; Carl Hirschie Johnson Journal: J Biol Rhythms Date: 2008-08 Impact factor: 3.182