Literature DB >> 12840898

DNA damage effects of hydroxyapatite ultrofine powder on W-256 sarcoma cells and lymphocytes in rats.

Q Xia1, P Hu, D Chen, J Zhang, Y Tian, J Zhang.   

Abstract

To explore the anticancer mechanism and DNA damages of hydroxyapatite ultrofine powder (HAUFP) on lymphocytes of rats, DNA damages in W-256 sarcoma cells and lymphocytes of rats were measured by single cell gel electrophoresis (SCGE). The results showed that HAUFP damaged DNA of W-256 sarcoma cells obviously but only cause slight damage of DNA of lymphocytes in rats. It is suggested that HAUFP selectively damaged DNA of tumor cells with only mild damage of lymphocyte DNA. HAUFP has powerful anticancer effect and little genetic toxicity.

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Year:  1999        PMID： 12840898     DOI： 10.1007/bf02887738

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  5 in total

1.  Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells.

Authors:  C M Gedik; S W Ewen; A R Collins
Journal:  Int J Radiat Biol       Date:  1992-09       Impact factor: 2.694

2.  A simple technique for quantitation of low levels of DNA damage in individual cells.

Authors:  N P Singh; M T McCoy; R R Tice; E L Schneider
Journal:  Exp Cell Res       Date:  1988-03       Impact factor: 3.905

3.  Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay.

Authors:  P L Olive; J P Banáth; R E Durand
Journal:  Radiat Res       Date:  1990-04       Impact factor: 2.841

4.  Liquid holding effects on methylmercury genotoxicity in human lymphocytes.

Authors:  C Betti; T Davini; J He; R Barale
Journal:  Mutat Res       Date:  1993-04       Impact factor: 2.433

5.  Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells.

Authors:  O Ostling; K J Johanson
Journal:  Biochem Biophys Res Commun       Date:  1984-08-30       Impact factor: 3.575
  5 in total
  1 in total

1.  The effect of hydroxyapatite ultrofine powder on the immunity function of tumor-bearing mice.

Authors:  Q Xia; H Nie; D Chen; Y Yan; L Feng; S Li
Journal:  J Tongji Med Univ       Date:  2001
  1 in total

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