Literature DB >> 12840865

Anti-proliferative effects induced by anti-CD4 human/murine chimeric antibody and murine anti-CD4 monoclonal antibody.

G Shen1, H Zhu, X Wang, Y Zhang, Z Zhu, S Wang.   

Abstract

The effects of chimeric anti-CD4 human/murine chimeric antibody and murine anti-CD4 monoclonal antibody (McAb) on the proliferation induced by anti-CD3 McAb, phytohemagglutinin (PHA), IL-2, and allogeneic cells were studied. The results showed that chimeric anti-CD4 antibody and murine anti-CD4 McAb could inhibit the proliferation induced by the above inducers and the inhibitory effects were related to the dosage of the antibodies.

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Year:  1999        PMID： 12840865     DOI： 10.1007/bf02895584

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  13 in total

1.  Down-regulation of cell surface CD4 molecule expression induced by anti-CD4 antibodies in human T lymphocytes.

Authors:  P Morel; C Vincent; J Wijdenes; J P Revillard
Journal:  Cell Immunol       Date:  1992-12       Impact factor: 4.868

2.  Anti-CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T cells.

Authors:  C Herzog; C Walker; W Müller; P Rieber; C Reiter; G Riethmüller; P Wassmer; H Stockinger; O Madic; W J Pichler
Journal:  J Autoimmun       Date:  1989-10       Impact factor: 7.094

3.  CD4 monoclonal antibody pairs for immunosuppression and tolerance induction.

Authors:  S Qin; S Cobbold; H Tighe; R Benjamin; H Waldmann
Journal:  Eur J Immunol       Date:  1987-08       Impact factor: 5.532

Review 4.  Distinct functions of CD8(CD4) are utilized at different stages of T-lymphocyte differentiation.

Authors:  K Eichmann; N W Boyce; R Schmidt-Ullrich; J I Jönsson
Journal:  Immunol Rev       Date:  1989-06       Impact factor: 12.988

5.  A primatized MAb to human CD4 causes receptor modulation, without marked reduction in CD4+ T cells in chimpanzees: in vitro and in vivo characterization of a MAb (IDEC-CE9.1) to human CD4.

Authors:  D Anderson; K Chambers; N Hanna; J Leonard; M Reff; R Newman; J Baldoni; D Dunleavy; M Reddy; R Sweet; A Truneh
Journal:  Clin Immunol Immunopathol       Date:  1997-07

6.  CD4 and CD25 monoclonal antibody cocktail in kidney transplant rejection prophylaxis: clinical results of a pilot study.

Authors:  C Mousson; Y Tanter; E Racadot; J Wijdenes; J M Chalopin; D Chevet; P Hervé; G Rifle
Journal:  Transplant Proc       Date:  1995-04       Impact factor: 1.066

Review 7.  Selective immunosuppression.

Authors:  L Adorini; J C Guéry; G Rodriguez-Tarduchy; S Trembleau
Journal:  Immunol Today       Date:  1993-06

8.  In vivo treatment with a monoclonal chimeric anti-CD4 antibody results in prolonged depletion of circulating CD4+ cells in chimpanzees.

Authors:  M Jonker; W Slingerland; G Treacy; P van Eerd; K Y Pak; E Wilson; S Tam; K Bakker; A F Lobuglio; P Rieber
Journal:  Clin Exp Immunol       Date:  1993-09       Impact factor: 4.330

9.  IL-2-resistant hyporesponsiveness induced by CD4 mAbs in OKT3-activated human T cells is reversed by CD45RA triggering.

Authors:  E Robinet; S Fournel; A Fatmi; J P Revillard
Journal:  Cell Immunol       Date:  1996-01-10       Impact factor: 4.868

10.  Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the alpha-chain of the human interleukin-2 receptor.

Authors:  W Weissenhorn; W Scheuer; B Kaluza; M Schwirzke; C Reiter; D Flieger; H Lenz; E H Weiss; E P Rieber; G Riethmüller
Journal:  Gene       Date:  1992-11-16       Impact factor: 3.688
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