Literature DB >> 12840852

Myosin-induced autoimmune myocarditis in BALB/C mice.

Z Wang1, Y Liao, J Dong, S Li, J Wang, Y Tu.   

Abstract

Experimental mice were immunized with cardiac myosin and complete Freund's adjuvant (CFA) on days 0, 7 and 30 and control mice were immunized with CFA. Sera and myocardium samples were harvested on days 15, 21 and 120 after the first immunization. Pathological findings demonstrated that there were necrosis and inflammatory infiltration in acute stage and fibrosis mainly in chronic stage of experimental group. Anti-myosin antibodies were also found in sera of experimental mice, but not in control group. Our study showed that cardiac myosin served as an autoantigen to provoke autoimmunity and lead to the transformation of VMC into DCM.

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Year:  1999        PMID： 12840852     DOI： 10.1007/bf02886889

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  5 in total

1.  Epitopes shared between coxsackievirus B3 (CVB3) and normal heart tissue contribute to CVB3-induced murine myocarditis.

Authors:  C J Gauntt; A L Higdon; H M Arizpe; M R Tamayo; R Crawley; R D Henkel; M E Pereira; S M Tracy; M W Cunningham
Journal:  Clin Immunol Immunopathol       Date:  1993-08

2.  Rat dilated cardiomyopathy after autoimmune giant cell myocarditis.

Authors:  M Kodama; H Hanawa; M Saeki; H Hosono; T Inomata; K Suzuki; A Shibata
Journal:  Circ Res       Date:  1994-08       Impact factor: 17.367

3.  Cardiac myosin induces myocarditis in genetically predisposed mice.

Authors:  N Neu; N R Rose; K W Beisel; A Herskowitz; G Gurri-Glass; S W Craig
Journal:  J Immunol       Date:  1987-12-01       Impact factor: 5.422

Review 4.  Cardiac contractile proteins and autoimmune myocarditis.

Authors:  T Izumi; H Hanawa; M Saeki; M Kodama
Journal:  Mol Cell Biochem       Date:  1993-02-17       Impact factor: 3.396

5.  Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin.

Authors:  M W Cunningham; S M Antone; J M Gulizia; B M McManus; V A Fischetti; C J Gauntt
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205
  5 in total
  1 in total

1.  Effect of anti-cardiac myosin antibody on prognosis of patients with acute myocardial infarction.

Authors:  H Pang; Y Liao; Z Wang; J Dong; Q Lu
Journal:  J Tongji Med Univ       Date:  2000
  1 in total

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