Bénédicte Leynaert1, David Soussan. 1. The French Institute of Health and Medical Research, INSERM Unité, Paris, France. leynaert@bichat.inserm.fr
Abstract
PURPOSE OF REVIEW: To review the results from recent studies that assessed the burden of allergic diseases on the patients' every-day life, or contributed to new advances in monitoring quality-of-life in allergic disorders. This review will not report the numerous clinical trials that included quality-of-life as an outcome. RECENT FINDINGS: Quality-of-life impairment was investigated in patients with asthma, allergic rhinitis, atopic dermatitis or food allergy. A new questionnaire was validated for patients with yellow jacket allergy. At the same time, the properties of formerly developed questionnaires were further investigated and tools were developed to assess factors related to quality-of-life, such as work functioning, or perceived control of the disease. SUMMARY: Allergic disorders are associated with a variety of limitations in the patients' daily life. The relative burden of concomitant disorders, however, has not been thoroughly investigated. When monitoring quality-of-life, investigators should ensure that the results are not biased by confounding factors that may affect quality-of-life. Moreover, the uncertainty around estimates of change in health status related to treatment and around standard thresholds for clinical significance should be taken into account before drawing inference as regards the treatment worthiness.
PURPOSE OF REVIEW: To review the results from recent studies that assessed the burden of allergic diseases on the patients' every-day life, or contributed to new advances in monitoring quality-of-life in allergic disorders. This review will not report the numerous clinical trials that included quality-of-life as an outcome. RECENT FINDINGS: Quality-of-life impairment was investigated in patients with asthma, allergic rhinitis, atopic dermatitis or food allergy. A new questionnaire was validated for patients with yellow jacket allergy. At the same time, the properties of formerly developed questionnaires were further investigated and tools were developed to assess factors related to quality-of-life, such as work functioning, or perceived control of the disease. SUMMARY:Allergic disorders are associated with a variety of limitations in the patients' daily life. The relative burden of concomitant disorders, however, has not been thoroughly investigated. When monitoring quality-of-life, investigators should ensure that the results are not biased by confounding factors that may affect quality-of-life. Moreover, the uncertainty around estimates of change in health status related to treatment and around standard thresholds for clinical significance should be taken into account before drawing inference as regards the treatment worthiness.
Authors: Hubert Chen; Miriam G Cisternas; Patricia P Katz; Theodore A Omachi; Laura Trupin; Edward H Yelin; John R Balmes; Paul D Blanc Journal: Ann Allergy Asthma Immunol Date: 2011-01-08 Impact factor: 6.347
Authors: Nikolaos G Papadopoulos; Ioana Agache; Sevim Bavbek; Beatrice M Bilo; Fulvio Braido; Victoria Cardona; Adnan Custovic; Jan Demonchy; Pascal Demoly; Philippe Eigenmann; Jacques Gayraud; Clive Grattan; Enrico Heffler; Peter W Hellings; Marek Jutel; Edward Knol; Jan Lötvall; Antonella Muraro; Lars K Poulsen; Graham Roberts; Peter Schmid-Grendelmeier; Chrysanthi Skevaki; Massimo Triggiani; Ronald Vanree; Thomas Werfel; Breda Flood; Susanna Palkonen; Roberta Savli; Pia Allegri; Isabella Annesi-Maesano; Francesco Annunziato; Dario Antolin-Amerigo; Christian Apfelbacher; Miguel Blanca; Ewa Bogacka; Patrizia Bonadonna; Matteo Bonini; Onur Boyman; Knut Brockow; Peter Burney; Jeroen Buters; Indre Butiene; Moises Calderon; Lars Olaf Cardell; Jean-Christoph Caubet; Sevcan Celenk; Ewa Cichocka-Jarosz; Cemal Cingi; Mariana Couto; Nicolette Dejong; Stefano Del Giacco; Nikolaos Douladiris; Filippo Fassio; Jean-Luc Fauquert; Javier Fernandez; Montserrat Fernandez Rivas; Marta Ferrer; Carsten Flohr; James Gardner; Jon Genuneit; Philippe Gevaert; Anna Groblewska; Eckard Hamelmann; Hans Jürgen Hoffmann; Karin Hoffmann-Sommergruber; Lilit Hovhannisyan; Valérie Hox; Frode L Jahnsen; Omer Kalayci; Ayse Füsun Kalpaklioglu; Jörg Kleine-Tebbe; George Konstantinou; Marcin Kurowski; Susanne Lau; Roger Lauener; Antti Lauerma; Kirsty Logan; Antoine Magnan; Joanna Makowska; Heidi Makrinioti; Paraskevi Mangina; Felicia Manole; Adriano Mari; Angel Mazon; Clare Mills; Ervinç Mingomataj; Bodo Niggemann; Gunnar Nilsson; Markus Ollert; Liam O'Mahony; Serena O'Neil; Gianni Pala; Alberto Papi; Gianni Passalacqua; Michael Perkin; Oliver Pfaar; Constantinos Pitsios; Santiago Quirce; Ulrike Raap; Monika Raulf-Heimsoth; Claudio Rhyner; Paula Robson-Ansley; Rodrigo Rodrigues Alves; Zeljka Roje; Carmen Rondon; Odilija Rudzeviciene; Franziska Ruëff; Maia Rukhadze; Gabriele Rumi; Cansin Sackesen; Alexandra F Santos; Annalisa Santucci; Christian Scharf; Carsten Schmidt-Weber; Benno Schnyder; Jürgen Schwarze; Gianenrico Senna; Svetlana Sergejeva; Sven Seys; Andrea Siracusa; Isabel Skypala; Milena Sokolowska; Francois Spertini; Radoslaw Spiewak; Aline Sprikkelman; Gunter Sturm; Ines Swoboda; Ingrid Terreehorst; Elina Toskala; Claudia Traidl-Hoffmann; Carina Venter; Berber Vlieg-Boerstra; Paul Whitacker; Margitta Worm; Paraskevi Xepapadaki; Cezmi A Akdis Journal: Clin Transl Allergy Date: 2012-11-02 Impact factor: 5.871