Young Yull Koh1, Chang Keun Kim. 1. Department of Pediatrics, Seoul National University Hospital, Seoul, Korea. kohyy@plaza.snu.ac.kr
Abstract
PURPOSE OF REVIEW: We will review data supporting the link between allergic rhinitis and asthma, examine recent progress made towards understanding the influence of allergic rhinitis on asthma regarding future development or progression of asthma, and discuss possible mechanisms through which this occurs and potential preventive measures. RECENT FINDINGS: Several recent reviews have concluded that a close relationship exists between allergic rhinitis and asthma. It has even been proposed that allergic rhinitis and asthma are manifestations of the same disease entity and that they represent a continuum of disease. Allergic rhinitis often precedes the onset of clinical asthma and is a risk factor for the development of asthma. Recognition of this relationship between allergic rhinitis and asthma is highlighted by the recent development of guidelines for the diagnosis and treatment of these disorders by the international Allergic Rhinitis and Its Impact on Asthma workshop. The mechanisms by which allergic rhinitis may be a risk factor for asthma are not entirely understood, although a few recent studies have addressed this question. Some clues in regard to the identification of subjects at risk of developing asthma have been provided by recent studies. Several recent reports support the belief that early introduction of immunotherapy in patients with allergic rhinitis reduces subsequent development of asthma, whereas it remains to be studied whether timely pharmacotherapy for allergic rhinitis may prevent the progression to asthma. SUMMARY: Because asthma is generally permanent at the time of diagnosis, it would be of great benefit to identify individuals at increased risk of developing asthma in order to provide a window of opportunity in which the progression to asthma could be prevented. As recognition and early treatment of allergic rhinitis could have important consequences in terms of reducing the prevalence and severity of asthma, there is a need to perform further clinical studies that address this issue.
PURPOSE OF REVIEW: We will review data supporting the link between allergic rhinitis and asthma, examine recent progress made towards understanding the influence of allergic rhinitis on asthma regarding future development or progression of asthma, and discuss possible mechanisms through which this occurs and potential preventive measures. RECENT FINDINGS: Several recent reviews have concluded that a close relationship exists between allergic rhinitis and asthma. It has even been proposed that allergic rhinitis and asthma are manifestations of the same disease entity and that they represent a continuum of disease. Allergic rhinitis often precedes the onset of clinical asthma and is a risk factor for the development of asthma. Recognition of this relationship between allergic rhinitis and asthma is highlighted by the recent development of guidelines for the diagnosis and treatment of these disorders by the international Allergic Rhinitis and Its Impact on Asthma workshop. The mechanisms by which allergic rhinitis may be a risk factor for asthma are not entirely understood, although a few recent studies have addressed this question. Some clues in regard to the identification of subjects at risk of developing asthma have been provided by recent studies. Several recent reports support the belief that early introduction of immunotherapy in patients with allergic rhinitis reduces subsequent development of asthma, whereas it remains to be studied whether timely pharmacotherapy for allergic rhinitis may prevent the progression to asthma. SUMMARY: Because asthma is generally permanent at the time of diagnosis, it would be of great benefit to identify individuals at increased risk of developing asthma in order to provide a window of opportunity in which the progression to asthma could be prevented. As recognition and early treatment of allergic rhinitis could have important consequences in terms of reducing the prevalence and severity of asthma, there is a need to perform further clinical studies that address this issue.
Authors: Gregor Hasler; Peter J Gergen; David G Kleinbaum; Vladeta Ajdacic; Alex Gamma; Dominique Eich; Wulf Rössler; Jules Angst Journal: Am J Respir Crit Care Med Date: 2005-03-11 Impact factor: 21.405