Literature DB >> 12839860

Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamine.

John S Mitcheson1.   

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Year:  2003        PMID： 12839860      PMCID： PMC1573930          DOI： 10.1038/sj.bjp.0705336

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


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  11 in total

1.  Blocker protection in the pore of a voltage-gated K+ channel and its structural implications.

Authors:  D del Camino; M Holmgren; Y Liu; G Yellen
Journal:  Nature       Date:  2000-01-20       Impact factor: 49.962

2.  Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

Authors:  J P Lees-Miller; Y Duan; G Q Teng; H J Duff
Journal:  Mol Pharmacol       Date:  2000-02       Impact factor: 4.436

Review 3.  Molecular and cellular mechanisms of cardiac arrhythmias.

Authors:  M T Keating; M C Sanguinetti
Journal:  Cell       Date:  2001-02-23       Impact factor: 41.582

4.  Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.

Authors:  Jun Chen; Guiscard Seebohm; Michael C Sanguinetti
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-03       Impact factor: 11.205

5.  Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.

Authors:  Liliana Pardo-López; Jesús García-Valdés; Georgina B Gurrola; Gail A Robertson; Lourival D Possani
Journal:  FEBS Lett       Date:  2002-01-02       Impact factor: 4.124

6.  Use-dependent block and use-dependent unblock of the delayed rectifier K+ current by almokalant in rabbit ventricular myocytes.

Authors:  E Carmeliet
Journal:  Circ Res       Date:  1993-11       Impact factor: 17.367

7.  Open channel block of HERG K(+) channels by vesnarinone.

Authors:  K Kamiya; J S Mitcheson; K Yasui; I Kodama; M C Sanguinetti
Journal:  Mol Pharmacol       Date:  2001-08       Impact factor: 4.436

8.  A structural basis for drug-induced long QT syndrome.

Authors:  J S Mitcheson; J Chen; M Lin; C Culberson; M C Sanguinetti
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

9.  Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.

Authors:  Jose A Sánchez-Chapula; Ricardo A Navarro-Polanco; Chris Culberson; Jun Chen; Michael C Sanguinetti
Journal:  J Biol Chem       Date:  2002-04-17       Impact factor: 5.157

10.  Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

Authors:  J S Mitcheson; J Chen; M C Sanguinetti
Journal:  J Gen Physiol       Date:  2000-03       Impact factor: 4.086
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  15 in total

1.  Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.

Authors:  Eberhard P Scholz; Edgar Zitron; Claudia Kiesecker; Sonja Lueck; Sven Kathöfer; Dierk Thomas; Slawomir Weretka; Simon Peth; Volker A W Kreye; Wolfgang Schoels; Hugo A Katus; Johann Kiehn; Christoph A Karle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-10-14       Impact factor: 3.000

2.  Allosteric effects of erythromycin pretreatment on thioridazine block of hERG potassium channels.

Authors:  W J Crumb
Journal:  Br J Pharmacol       Date:  2014-04       Impact factor: 8.739

Review 3.  Citalopram and cardiac toxicity.

Authors:  M J Cooke; W S Waring
Journal:  Eur J Clin Pharmacol       Date:  2012-09-21       Impact factor: 2.953

4.  Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.

Authors:  Sabrina Obers; Ingo Staudacher; Eckhard Ficker; Adrienne Dennis; Ronald Koschny; Hande Erdal; Ramona Bloehs; Jana Kisselbach; Christoph A Karle; Patrick A Schweizer; Hugo A Katus; Dierk Thomas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-03-13       Impact factor: 3.000

5.  Effects of antipsychotic drugs on I(to), I (Na), I (sus), I (K1), and hERG: QT prolongation, structure activity relationship, and network analysis.

Authors:  William J Crumb; Sean Ekins; R Dustan Sarazan; James H Wikel; Steven A Wrighton; Christopher Carlson; Charles M Beasley
Journal:  Pharm Res       Date:  2006-05-25       Impact factor: 4.200

6.  Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone.

Authors:  Edgar Zitron; Claudia Kiesecker; Eberhard Scholz; Sonja Lück; Ramona Bloehs; Sven Kathöfer; Dierk Thomas; Johann Kiehn; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-07-29       Impact factor: 3.000

7.  Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine.

Authors:  Hee-Kyung Hong; Su-Hyun Jo
Journal:  Korean J Physiol Pharmacol       Date:  2009-06-30       Impact factor: 2.016

8.  Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.

Authors:  Dierk Thomas; Bettina C Hammerling; Kezhong Wu; Anna-Britt Wimmer; Eckhard K Ficker; Glenn E Kirsch; Mary C Kochan; Barbara A Wible; Eberhard P Scholz; Edgar Zitron; Sven Kathöfer; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle; Johann Kiehn
Journal:  Br J Pharmacol       Date:  2004-05-17       Impact factor: 8.739

9.  Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin.

Authors:  Dierk Thomas; Anna-Britt Wimmer; Kezhong Wu; Bettina C Hammerling; Eckhard K Ficker; Yuri A Kuryshev; Johann Kiehn; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-04-20       Impact factor: 3.000

10.  Differential hERG ion channel activity of ultrasmall gold nanoparticles.

Authors:  Annika Leifert; Yu Pan; Anne Kinkeldey; Frank Schiefer; Julia Setzler; Olaf Scheel; Hera Lichtenbeld; Günter Schmid; Wolfgang Wenzel; Willi Jahnen-Dechent; Ulrich Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-29       Impact factor: 11.205
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