AIM: The aim of this study is to investigate the ultra structural difference of placentas in IUGR fetuses that were all found to have abnormal umbilical artery Doppler waveforms. METHODS: Nine placentas from 7 IUGR fetuses and 2 from healthy normal fetuses were evaluated by scanning electron microscopy. RESULTS: All of the placentas of IUGR fetuses who had abnormal umbilical artery Doppler flow antenatally were found to have a prominent increase in the amount of total blood vessels; these aberrant blood vessels had a very tortuous course and they showed increased branching when compared with placentas from uncomplicated term pregnancies. CONCLUSIONS: Our study showed that there is a clear difference in vascular ultra structure of the placentas of pregnancies with fetal growth restriction selected by abnormal umbilical artery Doppler flow test. IUGR seems to be a problem due to placental vascular insufficiency.
AIM: The aim of this study is to investigate the ultra structural difference of placentas in IUGR fetuses that were all found to have abnormal umbilical artery Doppler waveforms. METHODS: Nine placentas from 7 IUGR fetuses and 2 from healthy normal fetuses were evaluated by scanning electron microscopy. RESULTS: All of the placentas of IUGR fetuses who had abnormal umbilical artery Doppler flow antenatally were found to have a prominent increase in the amount of total blood vessels; these aberrant blood vessels had a very tortuous course and they showed increased branching when compared with placentas from uncomplicated term pregnancies. CONCLUSIONS: Our study showed that there is a clear difference in vascular ultra structure of the placentas of pregnancies with fetal growth restriction selected by abnormal umbilical artery Doppler flow test. IUGR seems to be a problem due to placental vascular insufficiency.
Authors: Kathirvel Gopalakrishnan; Jay S Mishra; Vijayakumar Chinnathambi; Kathleen L Vincent; Igor Patrikeev; Massoud Motamedi; George R Saade; Gary D Hankins; Kunju Sathishkumar Journal: Hypertension Date: 2016-01-18 Impact factor: 10.190
Authors: Ling-Jun Li; Izzuddin Aris; Lin Lin Su; Mya Thway Tint; Carol Yim-Lui Cheung; M Kamran Ikram; Peter Gluckman; Keith M Godfrey; Kok Hian Tan; George Yeo; Fabian Yap; Kenneth Kwek; Seang-Mei Saw; Yap-Seng Chong; Tien-Yin Wong; Yung Seng Lee Journal: PLoS One Date: 2015-04-24 Impact factor: 3.240