Literature DB >> 12837380

The platelet as a model for chemical genetics.

Robert Flaumenhaft1, Derek S Sim.   

Abstract

Chemical genetics is an emerging strategy in chemical biology that promises to bring the power of true genetics to mammalian systems and facilitate the transfer of biological discoveries to therapeutics. The platelet is an anucleate cell with several features that render it suitable for chemical genetic analysis. This review addresses the benefits and challenges of chemical genetics using platelets as a model system.

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Year:  2003        PMID： 12837380     DOI： 10.1016/s1074-5521(03)00127-3

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  3 in total

1.  Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.

Authors:  Louisa Dowal; Derek S Sim; James R Dilks; Price Blair; Sarah Beaudry; Bradley M Denker; Georgios Koukos; Athan Kuliopulos; Robert Flaumenhaft
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-31       Impact factor: 11.205

2.  Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.

Authors:  Chris Dockendorff; Omozuanvbo Aisiku; Lynn Verplank; James R Dilks; Daniel A Smith; Susanna F Gunnink; Louisa Dowal; Joseph Negri; Michelle Palmer; Lawrence Macpherson; Stuart L Schreiber; Robert Flaumenhaft
Journal:  ACS Med Chem Lett       Date:  2012-01-30       Impact factor: 4.345

3.  The piperazine compound ASP activates an auxin response in Arabidopsis thaliana.

Authors:  Fengyang Xu; Shuqi Xue; Limeng Deng; Sufen Zhang; Yaxuan Li; Xin Zhao
Journal:  BMC Genomics       Date:  2020-11-11       Impact factor: 3.969
  3 in total

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