Literature DB >> 1283726

The effects of purified 25-kDa lipase from a clinical isolate of Pseudomonas cepacia in the lungs of rats.

M K Lonon1, D E Woods, D C Straus.   

Abstract

Nanogram quantities of a 25-kDa lipase purified from culture supernatants of Pseudomonas cepacia 90ee, a sputum isolate from a cystic fibrosis (CF) patient, were placed in the lungs of healthy rats. The resulting pathological changes included large amounts of proteinaceous exudate, the accumulation of polymorphonuclear leukocytes and red blood cells, and disorganization of alveolar structure. Pseudomonas cepacia 90ee immobilized in agar beads was also placed in the lungs of rats in a model of chronic infection. This resulted in bronchopneumonia and a milder inflammatory response than that elicited by the purified enzyme.

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Year:  1992        PMID： 1283726     DOI： 10.1007/bf01570965

Source DB:  PubMed          Journal:  Curr Microbiol        ISSN： 0343-8651            Impact factor:   2.188


  13 in total

1.  Immune complexes in cystic fibrosis.

Authors:  H McFarlane; A Holzel; P Brenchley; J D Allan; J C Wallwork; B E Singer; B Worsley
Journal:  Br Med J       Date:  1975-02-22

2.  Effect of nutrient depletion on sensitivity of Pseudomonas cepacia to phagocytosis and serum bactericidal activity at different temperatures.

Authors:  H Anwar; M R Brown; P A Lambert
Journal:  J Gen Microbiol       Date:  1983-07

3.  A rat model of chronic respiratory infection with Pseudomonas aeruginosa.

Authors:  H A Cash; D E Woods; B McCullough; W G Johanson; J A Bass
Journal:  Am Rev Respir Dis       Date:  1979-03

4.  Pseudomonas cepacia infection in cystic fibrosis: an emerging problem.

Authors:  A Isles; I Maclusky; M Corey; R Gold; C Prober; P Fleming; H Levison
Journal:  J Pediatr       Date:  1984-02       Impact factor: 4.406

5.  Characterization of Pseudomonas cepacia isolates from patients with cystic fibrosis.

Authors:  A I McKevitt; D E Woods
Journal:  J Clin Microbiol       Date:  1984-02       Impact factor: 5.948

6.  Bacteremia in patients with cystic fibrosis.

Authors:  M M McCarthy; M H Rourk; A Spock
Journal:  Clin Pediatr (Phila)       Date:  1980-11       Impact factor: 1.168

7.  Production of an extracellular toxic complex by various strains of Pseudomonas cepacia.

Authors:  D C Straus; M K Lonon; D E Woods; C W Garner
Journal:  J Med Microbiol       Date:  1989-09       Impact factor: 2.472

8.  Purification and characterization of an extracellular protease from Pseudomonas cepacia.

Authors:  A I McKevitt; S Bajaksouzian; J D Klinger; D E Woods
Journal:  Infect Immun       Date:  1989-03       Impact factor: 3.441

9.  Pseudomonas cepacia colonization in patients with cystic fibrosis: risk factors and clinical outcome.

Authors:  O C Tablan; T L Chorba; D V Schidlow; J W White; K A Hardy; P H Gilligan; W M Morgan; L A Carson; W J Martone; J M Jason
Journal:  J Pediatr       Date:  1985-09       Impact factor: 4.406

10.  Production of lipase by clinical isolates of Pseudomonas cepacia.

Authors:  M K Lonon; D E Woods; D C Straus
Journal:  J Clin Microbiol       Date:  1988-05       Impact factor: 5.948
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  2 in total

1.  Secreted proteases from Actinobacillus pleuropneumoniae serotype 1 degrade porcine gelatin, hemoglobin and immunoglobulin A.

Authors:  E Negrete-Abascal; V R Tenorio; J J Serrano; C Garcia; M de la Garza
Journal:  Can J Vet Res       Date:  1994-04       Impact factor: 1.310

2.  Lipopolysaccharide of Burkholderia cepacia and its unique character to stimulate murine macrophages with relative lack of interleukin-1beta-inducing ability.

Authors:  H Shimomura; M Matsuura; S Saito; Y Hirai; Y Isshiki; K Kawahara
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441
  2 in total

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