Synthetic study of guanofosfocin. Synthesis of 8-(mannopyranosyloxy)inosine derivative.

As a basic study directed towards the synthesis of guanofosfocin analogues, preparation of a new class of nucleoside-carbohydrate hybrid has been investigated by two approaches; (1) glycosylation of 8-oxoinosine derivatives with mannopyranosyl bromide and (2) Mitsunobu reaction of 8-oxoinosine derivatives with protected mannopyranoses.