Literature DB >> 12835906

Micropropagation of Thapsia garganica--a medicinal plant.

N P Makunga1, A K Jäger, J Van Staden.   

Abstract

The micropropagation of T. garganica, a medicinally important plant, was investigated as an option for conservation purposes as wild populations are becoming sparse. A Murashige and Skoog agar medium supplemented with 0.5 mg l(-1) alpha-naphthaleneacetic acid and 1.5 mg l(-1) benzyl-6-adenine significantly improved the production of multiple shoots directly from petiole and leaflet explants compared to other plant growth regulator (PGR) combinations. Medium free of PGRs promoted rooting at a low incidence. Acclimatisation was low--52% plantlet survival--as micropropagated plantlets were highly susceptible to fungal rot once removed from culture. Application of antifungal agents to in vitro-derived plantlets as pre- and post-acclimatisation treatments during transplanting significantly reduced ex vitro mortality.

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Year:  2003        PMID: 12835906     DOI: 10.1007/s00299-003-0623-8

Source DB:  PubMed          Journal:  Plant Cell Rep        ISSN: 0721-7714            Impact factor:   4.570


  8 in total

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4.  Design, synthesis, and pharmacological evaluation of thapsigargin analogues for targeting apoptosis to prostatic cancer cells.

Authors:  C M Jakobsen; S R Denmeade; J T Isaacs; A Gady; C E Olsen; S B Christensen
Journal:  J Med Chem       Date:  2001-12-20       Impact factor: 7.446

5.  Phytochemistry of the genus Thapsia.

Authors:  U Rasmussen; S B Christensen; F Sandberg
Journal:  Planta Med       Date:  1981-12       Impact factor: 3.352

6.  Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Authors:  O Thastrup; P J Cullen; B K Drøbak; M R Hanley; A P Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

7.  Characterization of chromosomes and genome organization of Thapsia garganica L. by localizations of rRNA genes using fluorescent in situ hybridization.

Authors:  S K Rasmussen; P Avato
Journal:  Hereditas       Date:  1998       Impact factor: 3.271

8.  The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin.

Authors:  Y Furuya; P Lundmo; A D Short; D L Gill; J T Isaacs
Journal:  Cancer Res       Date:  1994-12-01       Impact factor: 12.701

  8 in total
  8 in total

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3.  Micropropagation, myristicin production enhancement, and comparative GC-MS analysis of the n-hexane extracts of different organs of Daucus pumilus (Gouan), family Apiaceae.

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Review 4.  Thapsigargin--from Thapsia L. to mipsagargin.

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5.  Chemical composition, antibacterial, antioxidant and insecticidal activities of moroccan Thapsia transtagana essential oil.

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6.  Perspectives on using physcomitrella patens as an alternative production platform for thapsigargin and other terpenoid drug candidates.

Authors:  Henrik Toft Simonsen; Damian Paul Drew; Christina Lunde
Journal:  Perspect Medicin Chem       Date:  2009-03-04

7.  Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica.

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8.  The Evaluation of Phenolic Acids and Flavonoids Content and Antiprotozoal Activity of Eryngium Species Biomass Produced by Biotechnological Methods.

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  8 in total

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