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Literature DB >> 12835673

Cancer genetics and drug discovery in the zebrafish.

Abstract

Fish have a long history of use in cancer toxicology studies, because they develop neoplasms that are histologically similar to human cancers. Because of considerable progress in zebrafish genetics and genomics over the past few years, the zebrafish system has provided many useful tools for studying basic biological processes. These tools include forward genetic screens, transgenic models, specific gene disruptions and small-molecule screens. By combining carcinogenesis assays, genetic analyses and small-molecule screening techniques, the zebrafish is emerging as a powerful system for identifying novel cancer genes and for cancer drug discovery.

Entities: Disease Species

Mesh：

Substances：
Antineoplastic Agents

Year: 2003 PMID： 12835673 DOI： 10.1038/nrc1126

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

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Cited

52 in total

1. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.

Authors: David M Langenau; Adolfo A Ferrando; David Traver; Jeffery L Kutok; John-Paul D Hezel; John P Kanki; Leonard I Zon; A Thomas Look; Nikolaus S Trede
Journal: Proc Natl Acad Sci U S A Date: 2004-05-03 Impact factor: 11.205

2. A novel zebrafish embryo xenotransplantation model to study primary human fibroblast motility in health and disease.

Authors: Alexey O Benyumov; Polla Hergert; Jeremy Herrera; Mark Peterson; Craig Henke; Peter B Bitterman
Journal: Zebrafish Date: 2012-02-22 Impact factor: 1.985

3. Transgenic expression of walleye dermal sarcoma virus rv-cyclin (orfA) in zebrafish does not result in tissue proliferation.

Authors: Thomas A Paul; Joel Rovnak; Sandra L Quackenbush; Kathleen Whitlock; Huiqing Zhan; Zhiyuan Gong; Jan Spitsbergen; Paul R Bowser; James W Casey
Journal: Mar Biotechnol (NY) Date: 2010-03-28 Impact factor: 3.619

4. A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.

Authors: Jennifer L Shepard; James F Amatruda; Howard M Stern; Aravind Subramanian; David Finkelstein; James Ziai; K Rose Finley; Kathleen L Pfaff; Candace Hersey; Yi Zhou; Bruce Barut; Matthew Freedman; Charles Lee; Jan Spitsbergen; Donna Neuberg; Gerhard Weber; Todd R Golub; Jonathan N Glickman; Jeffery L Kutok; Jon C Aster; Leonard I Zon
Journal: Proc Natl Acad Sci U S A Date: 2005-09-06 Impact factor: 11.205

10. Transgenic expression of walleye dermal sarcoma virus rv-cyclin gene in zebrafish and its suppressive effect on liver tumor development after carcinogen treatment.

Authors: Huiqing Zhan; Jan M Spitsbergen; Wei Qing; Yi Lian Wu; Thomas A Paul; James W Casey; Guor Muor Her; Zhiyuan Gong
Journal: Mar Biotechnol (NY) Date: 2010-01-06 Impact factor: 3.619

Cancer genetics and drug discovery in the zebrafish.

1. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.

2. A novel zebrafish embryo xenotransplantation model to study primary human fibroblast motility in health and disease.

3. Transgenic expression of walleye dermal sarcoma virus rv-cyclin (orfA) in zebrafish does not result in tissue proliferation.

4. A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.

5. Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.

6. Homologous recombination in zebrafish ES cells.

Review 7. Zebrafish kidney development: basic science to translational research.

Review 8. Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model.

9. Temozolomide-mediated radiosensitization of human glioma cells in a zebrafish embryonic system.

10. Transgenic expression of walleye dermal sarcoma virus rv-cyclin gene in zebrafish and its suppressive effect on liver tumor development after carcinogen treatment.