| Literature DB >> 12834921 |
Hyun Joon Kim1, Jeong Eun Kim, Myung Ha, Sang Soo Kang, Jong Tae Kim, In Sung Park, Sun Ha Paek, Hee-Won Jung, Dong Gyu Kim, Gyeong Jae Cho, Wan Sung Choi.
Abstract
In this study we found the expression of steroidogenic acute regulatory protein (StAR) mRNA and protein in both the normal human brain and intracranial tumors, using RT-PCR and immunohistochemistry. StAR mRNA is expressed at a very low level in the white matter of the normal human brain, but in tumoral tissues StAR mRNA was specifically expressed in oligodendrogliomas and malignant glial tumors. StAR-positive cells were also detected in the normal human brains and gliomas; its frequency and density were higher in glioma tissue. These findings suggest that StAR expression might be correlated with the growth of glial tumors.Entities:
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Year: 2003 PMID： 12834921 DOI： 10.1016/s0006-8993(03)02840-3
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252