| Literature DB >> 12834919 |
Myeung Ju Kim1, Kyeung Min Joo, Yoon Hee Chung, Yun Jung Lee, Jaehyup Kim, Bong Hee Lee, Dong Hoon Shin, Kyung Hoon Lee, Choong Ik Cha.
Abstract
Although there is much evidence showing that NO regulates the release of VIP in several areas, there is no report about the influence of NO on VIP in the cerebral cortex. We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization. The nNOS((-/-)) mice had significantly fewer VIP-immunoreactive neurons than the control mice and the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS((-/-)) mice. The first demonstration of decrease in VIP expression in the cerebral cortex of nNOS((-/-)) mice may provide useful data for investigating the relation between NO and VIP in the cerebral cortex and the mechanisms of many functions of these two neurotransmitters.Entities:
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Year: 2003 PMID： 12834919 DOI： 10.1016/s0006-8993(03)02950-0
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252