Literature DB >> 12834294

Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.

Keiko Iwata1, Shin Ogata, Katsuzumi Okumura, Hiroshi Taguchi.   

Abstract

Water-soluble vitamin, niacin, and its related compounds were examined for their differentiation-inducing activity in human promyelocytic leukemia cells (HL-60). Among the compounds, which inhibited cell proliferation measured by MTT assay, isonicotinic acid, nicotinamide N-oxide, and nicotinamide induced NBT reducing activity. HL-60 cells were differentiated into granulocyte-like cells by these compounds, judging from morphological changes and loss of nonspecific esterase activity. The differentiation-inducing activity of water-soluble vitamin and its related compounds suggest that these compounds may be applicable for medical use.

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Year:  2003        PMID： 12834294     DOI： 10.1271/bbb.67.1132

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

1.  Nicotinamide N-oxidation by CYP2E1 in human liver microsomes.

Authors:  Alexander Michael Real; Shangyu Hong; Pavlos Pissios
Journal:  Drug Metab Dispos       Date:  2012-12-21       Impact factor: 3.922

2.  Nicotinamide cooperates with retinoic acid and 1,25-dihydroxyvitamin D(3) to regulate cell differentiation and cell cycle arrest of human myeloblastic leukemia cells.

Authors:  Miaoqing Shen; Andrew Yen
Journal:  Oncology       Date:  2009-01-06       Impact factor: 2.935

3.  NAD Modulates DNA Methylation and Cell Differentiation.

Authors:  Simone Ummarino; Clinton Hausman; Giulia Gaggi; Lucrezia Rinaldi; Mahmoud A Bassal; Yanzhou Zhang; Andy Joe Seelam; Ikei S Kobayashi; Marta Borchiellini; Alexander K Ebralidze; Barbara Ghinassi; Bon Q Trinh; Susumu S Kobayashi; Annalisa Di Ruscio
Journal:  Cells       Date:  2021-11-02       Impact factor: 7.666

4.  Nicotinamide inhibits vasculogenic mimicry, an alternative vascularization pathway observed in highly aggressive melanoma.

Authors:  Orit Itzhaki; Eyal Greenberg; Bruria Shalmon; Adva Kubi; Avraham J Treves; Ronnie Shapira-Frommer; Camilla Avivi; Rona Ortenberg; Eytan Ben-Ami; Jacob Schachter; Michal J Besser; Gal Markel
Journal:  PLoS One       Date:  2013-02-25       Impact factor: 3.240

5.  Characterizing the Key Metabolic Pathways of the Neonatal Mouse Heart Using a Quantitative Combinatorial Omics Approach.

Authors:  Maciej M Lalowski; Susann Björk; Piet Finckenberg; Rabah Soliymani; Miikka Tarkia; Giulio Calza; Daria Blokhina; Sari Tulokas; Matti Kankainen; Päivi Lakkisto; Marc Baumann; Esko Kankuri; Eero Mervaala
Journal:  Front Physiol       Date:  2018-04-11       Impact factor: 4.566

6.  NAD metabolites interfere with proliferation and functional properties of THP-1 cells.

Authors:  Katharina Petin; Ronald Weiss; Gerd Müller; Antje Garten; Anja Grahnert; Ulrich Sack; Sunna Hauschildt
Journal:  Innate Immun       Date:  2019-05-03       Impact factor: 2.680

7.  Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α)/Hypoxia-Inducible Factor-2α (HIF2α) Signaling Pathway.

Authors:  Miao Liu; Pan Zhou; Jiaojiao Li; Yi Jiang
Journal:  Med Sci Monit       Date:  2020-05-29
  7 in total

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