Literature DB >> 12834008

Trypanocidal activity of extracts from Brazilian Atlantic Rain Forest plant species.

M G Pizzolatti1, A H Koga, E C Grisard, M Steindel.   

Abstract

The trypanocidal activity of crude hydro alcoholic extracts and several fractions of 13 plants from Brazilian Atlantic Rain Forest were tested in vitro against epimastigote and trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas disease. Crude ethanol extracts with promising in vitro activity (DL50 between 5-10 microg/ml) against epimastigotes were fractionated by solvent partition and further tested against bloodstream form of the parasite. Activity against bloodstream parasites was observed in both dichloromethane and hexane fractions of Polygala sabulosa and P. paniculata.

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Year:  2003        PMID： 12834008     DOI： 10.1078/0944-7113-00252

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  8 in total

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Journal:  Metab Brain Dis       Date:  2021-01-04       Impact factor: 3.584

3.  Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects.

Authors:  Felipe de Paula Nogueira Cruz; Ailton Ferreira de Paula; Camila Tita Nogueira; Paulo Henrique Marques de Andrade; Leonardo Maurici Borges; Paulo Teixeira Lacava; Ilana Lopes Baratella da Cunha Camargo; Fernanda de Freitas Aníbal; Cristina Paiva de Sousa
Journal:  Int J Microbiol       Date:  2021-02-17

4.  Leishmanicidal, Trypanocidal and Antioxidant Activity of Amyrin-Rich Extracts from Eugenia pyriformis Cambess.

Authors:  João H de Souza; Alexandra Michelon; Fernanda W Banhuk; Izabela V Staffen; Elissandro J Klein; Edson A da Silva; Rafael A Menolli
Journal:  Iran J Pharm Res       Date:  2020       Impact factor: 1.696

5.  Screening for antimicrobial activity of ten medicinal plants used in Colombian folkloric medicine: a possible alternative in the treatment of non-nosocomial infections.

Authors:  Jhon J Rojas; Veronica J Ochoa; Saul A Ocampo; John F Muñoz
Journal:  BMC Complement Altern Med       Date:  2006-02-17       Impact factor: 3.659

6.  Antifungal activity of five species of Polygala.

Authors:  Susana Johann; Beatriz G Mendes; Fabiana C Missau; Maria A de Resende; Moacir G Pizzolatti
Journal:  Braz J Microbiol       Date:  2011-09-01       Impact factor: 2.476

7.  Effects of a novel β-lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis.

Authors:  Danielle Oliveira Dos Anjos; Eliomara Sousa Sobral Alves; Vinicius Tomaz Gonçalves; Sheila Suarez Fontes; Mateus Lima Nogueira; Ana Márcia Suarez-Fontes; João Batista Neves da Costa; Fabricio Rios-Santos; Marcos André Vannier-Santos
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-10-12       Impact factor: 4.284

8.  Anti-trypanosomal screening of Salvadoran flora.

Authors:  Ulises G Castillo; Ayato Komatsu; Morena L Martínez; Jenny Menjívar; Marvin J Núñez; Yoshinori Uekusa; Yuji Narukawa; Fumiyuki Kiuchi; Junko Nakajima-Shimada
Journal:  J Nat Med       Date:  2021-09-16       Impact factor: 2.343
  8 in total

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