| Literature DB >> 12834001 |
B Singh1, M K Sharma, P R Meghwal, P M Sahu, S Singh.
Abstract
Arnebia hispidissima ethanolic extract, after chromatography, yielded a number of shikonin derivatives, which were identified as arnebin-5, arnebin-6, teracryl shikonin, arnebinone and acetyl shikonin. All these compounds were firstly reported from this plant species and evaluated to the anti-inflammatory activity of ethanolic extract and isolated shikonin derivatives, models with carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The observed results indicated that pre-treatment with arnebinone significantly inhibited the carrageenan-induced paw edema and also suppressed the development of chronic arthritis induced by CFA.Entities:
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Year: 2003 PMID: 12834001 DOI: 10.1078/0944-7113-00262
Source DB: PubMed Journal: Phytomedicine ISSN: 0944-7113 Impact factor: 5.340