| Literature DB >> 1283390 |
Abstract
The relative viscosity of Pseudomonas aeruginosa alginate was shown to increase markedly when combined with mucin, Ca2+ ions and the exopolysaccharide from Pseudomonas cepacia. The presence of such a heterodisperse polysaccharide solution significantly reduced the diffusion and hence antimicrobial activity of tobramycin and to a lesser extent ciprofloxacin against Ps. aeruginosa by factors of 90 and 2.5-fold respectively over a 5 h incubation period. The clinical implications of these results are discussed in relation to cystic fibrosis.Entities:
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Year: 1992 PMID： 1283390 DOI： 10.1111/j.1365-2672.1992.tb05009.x
Source DB: PubMed Journal: J Appl Bacteriol ISSN： 0021-8847