BACKGROUND: Ovarian failure is a frequent complication occurring after haematopoietic stem cell transplantion (SCT), which is generally ascribed to radiation treatment and antiblastic alkylating agents. METHODS: Ovarian morphology and function were studied in reproductive age women 12-24 months after allogeneic SCT (n = 23) received from an HLA identical sibling, or autologous SCT (n = 22). Thirteen allo-transplanted women were suffering from chronic graft-versus-host disease (cGVHD). RESULTS: Menstrual cycles recovered in two and four women in the allo- and auto-SCT groups respectively, being associated with younger age and longer period elapsed from transplant. There was no difference in previous use of alkylating agents between allo- and auto-transplantation, while corticosteroid treatment was longer and more recent in the allo-SCT group. Significantly higher gonadotrophin levels and lower estradiol were seen in the combined group of patients than in controls. In allo-transplanted women, androgens were also significantly lower than in controls. Ovarian and uterine volumes were lower in patients than in controls, and in the allo- than in the auto-transplanted women. Within the allo-SCT group, endocrine function and ovarian and uterine volumes were significantly lower in the patients suffering from cGVHD. CONCLUSIONS: Ovarian failure in SCT recipients is likely to be caused principally by myelo-ablative treatments, but the condition of gonadal and androgen insufficiency can be worsened by an altered immunomodulation in allogeneic setting.
BACKGROUND:Ovarian failure is a frequent complication occurring after haematopoietic stem cell transplantion (SCT), which is generally ascribed to radiation treatment and antiblastic alkylating agents. METHODS:Ovarian morphology and function were studied in reproductive age women 12-24 months after allogeneic SCT (n = 23) received from an HLA identical sibling, or autologous SCT (n = 22). Thirteen allo-transplanted women were suffering from chronic graft-versus-host disease (cGVHD). RESULTS: Menstrual cycles recovered in two and four women in the allo- and auto-SCT groups respectively, being associated with younger age and longer period elapsed from transplant. There was no difference in previous use of alkylating agents between allo- and auto-transplantation, while corticosteroid treatment was longer and more recent in the allo-SCT group. Significantly higher gonadotrophin levels and lower estradiol were seen in the combined group of patients than in controls. In allo-transplanted women, androgens were also significantly lower than in controls. Ovarian and uterine volumes were lower in patients than in controls, and in the allo- than in the auto-transplanted women. Within the allo-SCT group, endocrine function and ovarian and uterine volumes were significantly lower in the patients suffering from cGVHD. CONCLUSIONS:Ovarian failure in SCT recipients is likely to be caused principally by myelo-ablative treatments, but the condition of gonadal and androgen insufficiency can be worsened by an altered immunomodulation in allogeneic setting.
Authors: Debra L Friedman; Alicia Rovo; Wendy Leisenring; Anna Locasciulli; Mary E D Flowers; Andre Tichelli; Jean E Sanders; H Joachim Deeg; Gerard Socie Journal: Blood Date: 2007-10-02 Impact factor: 22.113
Authors: B Serio; L Pezzullo; R Fontana; S Annunziata; R Rosamilio; M Sessa; V Giudice; I Ferrara; M Rocco; G De Rosa; P Ricci; L Tauchmanovà; N Montuori; C Selleri Journal: Transl Med UniSa Date: 2013-01-04
Authors: Paolo Laperuta; Filomena Napolitano; Rosa Maria Di Crescenzo; Pio Zeppa; Antonio Galderisi; Carmine Selleri; Alessandro Vatrella; Mario Capunzo; Vincenzo Giuseppe Di Crescenzo Journal: Open Med (Wars) Date: 2016-11-19
Authors: Carolina Vitale; Antonio Galderisi; Angelantonio Maglio; Paolo Laperuta; Rosa Maria Di Crescenzo; Carmine Selleri; Antonio Molino; Alessandro Vatrella Journal: Open Med (Wars) Date: 2016-11-19