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Literature DB >> 12829856

Differential hyperacetylation of histones H3 and H4 upon promoter-specific recruitment of EBNA2 in Epstein-Barr virus chromatin.

Nathalie Alazard¹, Henri Gruffat, Edwige Hiriart, Alain Sergeant, Evelyne Manet.

Abstract

Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transcriptional activator involved in the immortalization of B lymphocytes by the virus. EBNA2 is targeted to the promoters of its responsive genes, via interaction with cellular DNA-binding proteins. Using chromatin immunoprecipitation assays, we show for the first time the conditional recruitment of EBNA2 on two specific viral promoters in vivo and demonstrate a correlation between this recruitment and a local change in the acetylation of histones H3 and H4, which is promoter dependent.

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Year: 2003 PMID： 12829856 PMCID： PMC161941 DOI： 10.1128/jvi.77.14.8166-8172.2003

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

34 in total

1. PU box-binding transcription factors and a POU domain protein cooperate in the Epstein-Barr virus (EBV) nuclear antigen 2-induced transactivation of the EBV latent membrane protein 1 promoter.

Authors: A Sjöblom; A Jansson; W Yang; S Laín; T Nilsson; L Rymo
Journal: J Gen Virol Date: 1995-11 Impact factor: 3.891

2. Analysis of chromatin structure by in vivo formaldehyde cross-linking.

Authors: V Orlando; H Strutt; R Paro
Journal: Methods Date: 1997-02 Impact factor: 3.608

Review 3. Histone acetylation in chromatin structure and transcription.

Authors: M Grunstein
Journal: Nature Date: 1997-09-25 Impact factor: 49.962

4. Epstein-Barr virus nuclear antigen 2-estrogen receptor fusion proteins transactivate viral and cellular genes and interact with RBP-J kappa in a conditional fashion.

Authors: B Kempkes; M Pawlita; U Zimber-Strobl; G Eissner; G Laux; G W Bornkamm
Journal: Virology Date: 1995-12-20 Impact factor: 3.616

5. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.

Authors: X Tong; R Drapkin; R Yalamanchili; G Mosialos; E Kieff
Journal: Mol Cell Biol Date: 1995-09 Impact factor: 4.272

6. Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1.

Authors: D Y Wu; G V Kalpana; S P Goff; W H Schubach
Journal: J Virol Date: 1996-09 Impact factor: 5.103

7. The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2.

Authors: X Tong; R Drapkin; D Reinberg; E Kieff
Journal: Proc Natl Acad Sci U S A Date: 1995-04-11 Impact factor: 11.205

8. RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2.

Authors: L Waltzer; P Y Bourillot; A Sergeant; E Manet
Journal: Nucleic Acids Res Date: 1995-12-25 Impact factor: 16.971

9. The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.

Authors: L Waltzer; F Logeat; C Brou; A Israel; A Sergeant; E Manet
Journal: EMBO J Date: 1994-12-01 Impact factor: 11.598

10. The Spi-1/PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-J kappa interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element.

Authors: G Laux; B Adam; L J Strobl; F Moreau-Gachelin
Journal: EMBO J Date: 1994-12-01 Impact factor: 11.598

21 in total

1. The Epstein-Barr virus BcRF1 gene product is a TBP-like protein with an essential role in late gene expression.

Authors: Henri Gruffat; Faouzi Kadjouf; Bernard Mariamé; Evelyne Manet
Journal: J Virol Date: 2012-03-28 Impact factor: 5.103

2. Dynamic chromatin boundaries delineate a latency control region of Epstein-Barr virus.

Authors: Charles M Chau; Paul M Lieberman
Journal: J Virol Date: 2004-11 Impact factor: 5.103

3. Methylation status of the Epstein-Barr virus (EBV) BamHI W latent cycle promoter and promoter activity: analysis with novel EBV-positive Burkitt and lymphoblastoid cell lines.

Authors: Isabel A Hutchings; Rosemary J Tierney; Gemma L Kelly; Julianna Stylianou; Alan B Rickinson; Andrew I Bell
Journal: J Virol Date: 2006-08-18 Impact factor: 5.103

Differential hyperacetylation of histones H3 and H4 upon promoter-specific recruitment of EBNA2 in Epstein-Barr virus chromatin.

1. PU box-binding transcription factors and a POU domain protein cooperate in the Epstein-Barr virus (EBV) nuclear antigen 2-induced transactivation of the EBV latent membrane protein 1 promoter.

2. Analysis of chromatin structure by in vivo formaldehyde cross-linking.

Review 3. Histone acetylation in chromatin structure and transcription.

4. Epstein-Barr virus nuclear antigen 2-estrogen receptor fusion proteins transactivate viral and cellular genes and interact with RBP-J kappa in a conditional fashion.

5. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.

6. Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1.

7. The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2.

8. RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2.

9. The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.

10. The Spi-1/PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-J kappa interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element.

1. The Epstein-Barr virus BcRF1 gene product is a TBP-like protein with an essential role in late gene expression.

2. Dynamic chromatin boundaries delineate a latency control region of Epstein-Barr virus.

3. Methylation status of the Epstein-Barr virus (EBV) BamHI W latent cycle promoter and promoter activity: analysis with novel EBV-positive Burkitt and lymphoblastoid cell lines.

4. Chromatin profiling of Epstein-Barr virus latency control region.

5. Regulation of Epstein-Barr virus latency type by the chromatin boundary factor CTCF.

6. During lytic infections, herpes simplex virus type 1 DNA is in complexes with the properties of unstable nucleosomes.

7. CTCF prevents the epigenetic drift of EBV latency promoter Qp.

Review 8. Keeping it quiet: chromatin control of gammaherpesvirus latency.

9. Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells.

10. Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes.