Literature DB >> 12829417

Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture.

C Hurtado-Guzmán1, P Martínez-Alvarado, A Dagnino-Subiabre, I Paris, P Caviedes, R Caviedes, B K Cassels, J Segura-Aguilar.   

Abstract

Monoamine oxidase-A (MAO-A) [amiflamine (AMF) and 4-methylthioamphetamine (MTA)] and MAO-B (L-deprenyl) inhibitors were found to be cytotoxic in a concentration-dependent manner for RCHT cells derived from adult rat hypothalamus. The cytotoxic effects were increased when the inhibitors were co-incubated with dicoumarol and especially with 25 micro M AMF+100 micro M dicoumarol (2.5-fold; P <0.001). The treatment of RCHT cells solely with AMF induced a marked decrease in the expression of DT-diaphorase mRNA.

Entities:  

Year:  2002        PMID： 12829417     DOI： 10.1080/10298420290015944

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  9 in total

1.  Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome.

Authors:  A Dagnino-Subiabre; K Marcelain; C Arriagada; I Paris; P Caviedes; R Caviedes; J Segura-Aguilar
Journal:  Mol Cell Biochem       Date:  2000-09       Impact factor: 3.396

2.  Neuroprotection by (R)-deprenyl and 7-nitroindazole in the MPTP C57BL/6 mouse model of neurotoxicity.

Authors:  K Castagnoli; S Palmer; N Castagnoli
Journal:  Neurobiology (Bp)       Date:  1999

3.  Superoxide dismutase and catalase enhance autoxidation during one-electron reduction of aminochrome by NADPH-cytochrome P-450 reductase.

Authors:  S Baez; Y Linderson; J Segura-Aguilar
Journal:  Biochem Mol Med       Date:  1995-02

4.  Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line.

Authors:  I Paris; A Dagnino-Subiabre; K Marcelain; L B Bennett; P Caviedes; R Caviedes; C O Azar; J Segura-Aguilar
Journal:  J Neurochem       Date:  2001-04       Impact factor: 5.372

5.  L-Deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP(+) and beta-carbolinium: a microdialysis study in rats.

Authors:  K Matsubara; T Senda; T Uezono; T Awaya; S Ogawa; K Chiba; K Shimizu; N Hayase; K Kimura
Journal:  Neurosci Lett       Date:  2001-04-20       Impact factor: 3.046

6.  Apoptotic and antiapoptotic effect of (-)deprenyl and (-)-desmethyl-deprenyl on human cell lines.

Authors:  B Szende; K Magyar; Z Szegedi
Journal:  Neurobiology (Bp)       Date:  2000

7.  Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives: structure-activity relationships.

Authors:  M C Scorza; C Carrau; R Silveira; G Zapata-Torres; B K Cassels; M Reyes-Parada
Journal:  Biochem Pharmacol       Date:  1997-12-15       Impact factor: 5.858

8.  Calcium fluxes, ion currents and dihydropyridine receptors in a new immortal cell line from rat heart muscle.

Authors:  P Caviedes; E Olivares; K Salas; R Caviedes; E Jaimovich
Journal:  J Mol Cell Cardiol       Date:  1993-07       Impact factor: 5.000

9.  p-methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent.

Authors:  X Huang; D Marona-Lewicka; D E Nichols
Journal:  Eur J Pharmacol       Date:  1992-12-08       Impact factor: 4.432
  9 in total
  2 in total

1.  Neurotoxicological and neuroprotective elements in Parkinson's disease.

Authors:  Richard M. Kostrzewa; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2002-03       Impact factor: 3.911

2.  Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model.

Authors:  Jing Huang; Fangkun Liu; Hui Tang; Haishan Wu; Lehua Li; Renrong Wu; Jingping Zhao; Ying Wu; Zhixiong Liu; Jindong Chen
Journal:  Front Neurol       Date:  2017-12-07       Impact factor: 4.003
  2 in total

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