| Literature DB >> 12829328 |
Abba J Kastin1, Victoria Akerstrom, Weihong Pan.
Abstract
Interleukin (IL)-10 exerts beneficial effects on the central nervous system (CNS) after peripheral administration, but its penetration across the blood-brain barrier (BBB) has not been quantified. We show that 125I-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted.Entities:
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Year: 2003 PMID： 12829328 DOI： 10.1016/s0169-328x(03)00167-0
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X