H Gil1, N Magy, F Mauny, J-L Dupond. 1. Service de médecine interne, praticien hospitalier, centre hospitalier universitaire Jean-Minjoz, 25000, Besançon, France. hgil@chu-besancon.fr <hgil@chu-besancon.fr>
Abstract
PURPOSE: The value of eosinopenia as a test in favour of an infectious disease was suggested by Schilling since 1929. We tried to verify this hypothesis with a prospective and multicentric study. PATIENTS AND METHODS: One thousand and thirty-eight patients were included (82 females and 56 males, means age: 71.8 years). Diagnoses were: 83 infectious diseases, 38 systemic diseases, 10 neoplasia and 7 miscellaneous. RESULTS: The mean value of eosinophils was 72/mm3 in bacterial infectious diseases and 214/mm3 in non infectious diseases (p < 0.01). When leukocytes were higher than 10,000/mm3 and eosinophils counts less than 40/mm3, predictive value for an infectious bacterial disease was 100% as well as specificity. Under same conditions, when protein C reactive was higher than 100mg x l(-1), the predictive value was 85% and the specificity was 57%. CONCLUSION: Our study shows that an inflammatory syndrome associated with hyperleucocytosis above 10,000/mm3 and eosinophils counts under 40/mm3 seems strongly related to bacterial infectious diseases.
PURPOSE: The value of eosinopenia as a test in favour of an infectious disease was suggested by Schilling since 1929. We tried to verify this hypothesis with a prospective and multicentric study. PATIENTS AND METHODS: One thousand and thirty-eight patients were included (82 females and 56 males, means age: 71.8 years). Diagnoses were: 83 infectious diseases, 38 systemic diseases, 10 neoplasia and 7 miscellaneous. RESULTS: The mean value of eosinophils was 72/mm3 in bacterial infectious diseases and 214/mm3 in non infectious diseases (p < 0.01). When leukocytes were higher than 10,000/mm3 and eosinophils counts less than 40/mm3, predictive value for an infectious bacterial disease was 100% as well as specificity. Under same conditions, when protein C reactive was higher than 100mg x l(-1), the predictive value was 85% and the specificity was 57%. CONCLUSION: Our study shows that an inflammatory syndrome associated with hyperleucocytosis above 10,000/mm3 and eosinophils counts under 40/mm3 seems strongly related to bacterial infectious diseases.
Authors: Yoon Hee Kim; Hyun Bin Park; Min Jung Kim; Hwan Soo Kim; Hee Seon Lee; Yoon Ki Han; Kyung Won Kim; Myung Hyun Sohn; Kyu-Earn Kim Journal: J Korean Med Sci Date: 2013-01-08 Impact factor: 2.153
Authors: Roser Terradas; Santiago Grau; Jordi Blanch; Marta Riu; Pere Saballs; Xavier Castells; Juan Pablo Horcajada; Hernando Knobel Journal: PLoS One Date: 2012-08-09 Impact factor: 3.240