| Literature DB >> 12828607 |
Yasuhiro Ito1, Hiroshi Yoshida, Kotaro Shibahara, Takashi Uruno, Keiichi Nakano, Yuuki Takamura, Akihiro Miya, Kaoru Kobayashi, Tamotsu Yokozawa, Fumio Matsuzuka, Takeshi Uchimi, Michihiko Kuwano, Eiji Miyoshi, Nariaki Matsuura, Kanji Kuma, Akira Miyauchi.
Abstract
Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.Entities:
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Year: 2003 PMID： 12828607 DOI： 10.1046/j.1440-1827.2003.01494.x
Source DB: PubMed Journal: Pathol Int ISSN： 1320-5463 Impact factor: 2.534