OBJECTIVES: The aim of this study was to investigate selected hormones and immunologic markers in manganese alloy production workers with current and long-term manganese exposure. METHODS: One hundred randomly selected male workers exposed to manganese were compared with 100 male referents (matched for age) from similar process industries in a cross-sectional design. RESULTS: The geometric mean of the exposed workers' urinary manganese concentration was 0.9 (range 0.1-126.3) nmol/mmol creatinine (Cr) versus 0.4 (range 0.1-13.1) nmol/mmol Cr for the referents. The mean duration of exposure to manganese was 20.0 (range 2.1-41.0) years. The geometric mean of the prolactin serum concentration was higher for the exposed subjects than for the referents (229 versus 197 mIE/l, P=0.06). Serum prolactin was associated with current exposure to "soluble inhalable manganese", duration of exposure, and smoking habits. The subjects with the longest duration of exposure to manganese or the highest current exposure to "soluble inhalable manganese" had a statistically significantly higher serum prolactin concentration than the referents. The smokers had a lower serum prolactin concentration than the nonsmokers. The concentrations of the measured immunologic markers were similar in the groups. CONCLUSIONS: The study indicates that manganese exposure can increase the serum prolactin concentration. Both duration and current level of exposure are related to the slight increase, which also appears to be modified by current smoking habits. The serum prolactin concentrations were generally within the reference limits of the laboratory and thus not suitable as an exposure marker at these exposure levels.
OBJECTIVES: The aim of this study was to investigate selected hormones and immunologic markers in manganese alloy production workers with current and long-term manganese exposure. METHODS: One hundred randomly selected male workers exposed to manganese were compared with 100 male referents (matched for age) from similar process industries in a cross-sectional design. RESULTS: The geometric mean of the exposed workers' urinary manganese concentration was 0.9 (range 0.1-126.3) nmol/mmol creatinine (Cr) versus 0.4 (range 0.1-13.1) nmol/mmol Cr for the referents. The mean duration of exposure to manganese was 20.0 (range 2.1-41.0) years. The geometric mean of the prolactin serum concentration was higher for the exposed subjects than for the referents (229 versus 197 mIE/l, P=0.06). Serum prolactin was associated with current exposure to "soluble inhalable manganese", duration of exposure, and smoking habits. The subjects with the longest duration of exposure to manganese or the highest current exposure to "soluble inhalable manganese" had a statistically significantly higher serum prolactin concentration than the referents. The smokers had a lower serum prolactin concentration than the nonsmokers. The concentrations of the measured immunologic markers were similar in the groups. CONCLUSIONS: The study indicates that manganese exposure can increase the serum prolactin concentration. Both duration and current level of exposure are related to the slight increase, which also appears to be modified by current smoking habits. The serum prolactin concentrations were generally within the reference limits of the laboratory and thus not suitable as an exposure marker at these exposure levels.
Authors: Rita Bast-Pettersen; Dag G Ellingsen; Siri M Hetland; Yngvar Thomassen Journal: Int Arch Occup Environ Health Date: 2004-03-13 Impact factor: 3.015
Authors: John D Meeker; Mary G Rossano; Bridget Protas; Michael P Diamond; Elizabeth Puscheck; Douglas Daly; Nigel Paneth; Julia J Wirth Journal: Environ Res Date: 2009-10 Impact factor: 6.498
Authors: Nathália Ribeiro Dos Santos; Juliana Lima Gomes Rodrigues; Matheus de Jesus Bandeira; Ana Laura Dos Santos Anjos; Cecília Freitas da Silva Araújo; Luis Fernando Fernandes Adan; José Antonio Menezes-Filho Journal: Int J Environ Res Public Health Date: 2022-06-10 Impact factor: 4.614